Heart failure and inflammation-related biomarkers as predictors of new-onset diabetes in the general populationSuthahar, N., Meijers, W. C., Brouwers, F. P., Heerspink, H. J. L., Gansevoort, R. T., van der Harst, P., Bakker, S. J. L. & de Boer, R. A. 1-Jan-2018 In : International Journal of Cardiology. 250, p. 188-194 7 p.
Research output: Contribution to journal › Article
- Groningen Kidney Center (GKC)
- Methods in Medicines evaluation & Outcomes research (M2O)
- Cardiovascular Centre (CVC)
- Groningen Institute for Organ Transplantation (GIOT)
- Lifestyle Medicine (LM)
- Center for Medical Imaging (CMI)
- Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)
Background: There is a strong reciprocal relationship between heart failure (HF) and diabetes mellitus (DM). Shared pathophysiological mechanisms might be a possible explanation. Therefore, we hypothesised that biomarkers linked to HF would also predict new-onset type 2 DM in the general population.
Methods and results: We utilized the Prevention of Vascular and Renal End-stage Disease (PREVEND) cohort (mean age 48.9 years, 51% female) to study the relationship between HF and DM in 7953 participants free of baseline HF and DM. Multiple HF-related, inflammation-related and renal function-related biomarkers were evaluated regarding their predictive utility in new-onset DM. Incidence of DM in participants who developed HF was 11.8%, versus 5.4% in those who had not developed HF (p <0.001). Incidence of HF in participants who developed DM was 8.5%, versus 3.8% in those who had not developed DM (p <0.001). Classical HF biomarkers, NT-proBNP and hs-TnT were not associated with an increased risk for new-onset DM. However, inflammatory biomarkers hs-CRP [hazard ratio (HR) 1.16, (95% CI 1.05 to 1.29), p = 0.005], procalcitonin [HR 1.34, (95% CI 1.07 to 1.69), p = 0.012] and PAI-1 [HR 1.55, (95% CI 1.37 to 1.75), p <0.001] remained significantly associated with new-onset DM, even after multivariable adjustment for established predictors of DM.
Conclusions: Although HF and DM have a strong correlation with each other, systemic biomarkers that predict HF do not have a predictive value in new-onset DM. This suggests that other, indirect, pathophysiological mechanisms related to inflammation may explain their strong relation. (C) 2017 Elsevier B.V. All rights reserved.
|Number of pages||7|
|Journal||International Journal of Cardiology|
|State||Published - 1-Jan-2018|
- Heart Failure (HF), Diabetes Mellitus (DM), New-onset, Biomarkers, Inflammation, C-REACTIVE PROTEIN, PLASMINOGEN-ACTIVATOR INHIBITOR-1, COMMUNITY-BASED COHORT, INSULIN-RESISTANCE, NATRIURETIC PEPTIDE, CARDIOVASCULAR EVENTS, CARDIAC METABOLISM, PROGNOSTIC VALUE, ADIPOSE-TISSUE, FOLLOW-UP
Gansevoort, R. (Creator), University of Groningen, 2017
Bakker, S. (Creator), Dotinga, A. (Creator), Vonk, J. (Creator), Smidt, N. (Creator), Scholtens, S. (Creator), Swertz, M. (Creator), Wijmenga, C. (Creator), Wolffenbuttel, B. (Creator), Stolk, R. (Creator), Zon, van, S. (Creator), Rosmalen, J. (Creator), Postma, D. S. (Creator), Boer, de, R. (Creator), Navis, G. (Creator), Slaets, J. (Creator), Ormel, J. (Creator), Dijk, van, F. (Creator), Lifelines, 2006