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Heart failure and inflammation-related biomarkers as predictors of new-onset diabetes in the general population

Suthahar, N., Meijers, W. C., Brouwers, F. P., Heerspink, H. J. L., Gansevoort, R. T., van der Harst, P., Bakker, S. J. L. & de Boer, R. A. 1-Jan-2018 In : International Journal of Cardiology. 250, p. 188-194 7 p.

Research output: Contribution to journalArticle

Background: There is a strong reciprocal relationship between heart failure (HF) and diabetes mellitus (DM). Shared pathophysiological mechanisms might be a possible explanation. Therefore, we hypothesised that biomarkers linked to HF would also predict new-onset type 2 DM in the general population.

Methods and results: We utilized the Prevention of Vascular and Renal End-stage Disease (PREVEND) cohort (mean age 48.9 years, 51% female) to study the relationship between HF and DM in 7953 participants free of baseline HF and DM. Multiple HF-related, inflammation-related and renal function-related biomarkers were evaluated regarding their predictive utility in new-onset DM. Incidence of DM in participants who developed HF was 11.8%, versus 5.4% in those who had not developed HF (p <0.001). Incidence of HF in participants who developed DM was 8.5%, versus 3.8% in those who had not developed DM (p <0.001). Classical HF biomarkers, NT-proBNP and hs-TnT were not associated with an increased risk for new-onset DM. However, inflammatory biomarkers hs-CRP [hazard ratio (HR) 1.16, (95% CI 1.05 to 1.29), p = 0.005], procalcitonin [HR 1.34, (95% CI 1.07 to 1.69), p = 0.012] and PAI-1 [HR 1.55, (95% CI 1.37 to 1.75), p <0.001] remained significantly associated with new-onset DM, even after multivariable adjustment for established predictors of DM.

Conclusions: Although HF and DM have a strong correlation with each other, systemic biomarkers that predict HF do not have a predictive value in new-onset DM. This suggests that other, indirect, pathophysiological mechanisms related to inflammation may explain their strong relation. (C) 2017 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)188-194
Number of pages7
JournalInternational Journal of Cardiology
Volume250
StatePublished - 1-Jan-2018

    Keywords

  • Heart Failure (HF), Diabetes Mellitus (DM), New-onset, Biomarkers, Inflammation, C-REACTIVE PROTEIN, PLASMINOGEN-ACTIVATOR INHIBITOR-1, COMMUNITY-BASED COHORT, INSULIN-RESISTANCE, NATRIURETIC PEPTIDE, CARDIOVASCULAR EVENTS, CARDIAC METABOLISM, PROGNOSTIC VALUE, ADIPOSE-TISSUE, FOLLOW-UP
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