Health-Related Quality of Life of Patients with HPV-Related Cancers in Indonesia

Setiawan, D., Dusafitri, A., Galistiani, G. F., van Asselt, A. D. I. & Postma, M. J., 1-May-2018, In : Value in Health Regional Issues. 15, p. 63-69 7 p.

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BACKGROUND: Human papillomavirus (HPV)-related cancers are a serious concern in developing countries. Valid estimates of a country-specific health-related quality of life (HRQOL) for patients with HPV-related cancers provide a substantial tool in determining the burden of the disease.

OBJECTIVES: To investigate the HRQOL of patients with HPV-related cancers in Indonesia.

METHODS: The HRQOL of patients with HPV-related cancers (cervical, uterine, nasopharyngeal, head and neck, and anogenital cancer) was assessed using the EuroQol five-dimensional questionnaire (EQ-5D). Validity and reliability were assessed by means of construct validity and test-retest reliability methods, respectively. Subsequently, the EQ-5D utility index was calculated using the Thailand value set.

RESULTS: The EQ-5D came out as a valid and reliable questionnaire for measuring the HRQOL of patients with HPV-related cancers in Indonesia. From a total of 520 patients diagnosed with HPV-related cancers, 404 patients were excluded because of not fulfilling the inclusion criteria, and so 116 patients finally participated in the study. The mean age of the patients was 47.5 ± 12.03 years. Most of the patients were women (56.0%) and married (97.4%), and less than half of them had finished high school (32.7%). Moreover, the proportions of nasopharyngeal, cervical, head and neck, anogenital, and uterine cancers in the study population were 29.3%, 24.6%, 22.4%, 14.2%, and 9.5%, respectively. The average HRQOL of the patients with HPV-related cancers was 0.69 ± 0.10, with the highest and lowest estimates applying to uterine cancer (0.84 ± 0.29) and head and neck cancer (0.58 ± 0.33), respectively.

CONCLUSIONS: The HRQOL of patients with HPV-related cancers was found to be reduced to a certain extent in our study for Indonesia.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalValue in Health Regional Issues
Early online date3-Sep-2017
Publication statusPublished - 1-May-2018


  • cervical cancer, health-related quality of life, HPV-related cancer, human papillomavirus, Indonesia, adult, anus cancer, article, cancer patient, controlled study, cross-sectional study, descriptive research, female, genital tract cancer, head and neck cancer, human, major clinical study, male, malignant neoplasm, nasopharynx cancer, pilot study, priority journal, quality of life, uterine cervix cancer, uterus cancer, Wart virus

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