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Health related quality of life impact from rotavirus diarrhea on children and their family caregivers in Thailand
Rochanathimoke, O., Riewpaiboon, A., Postma, M. J., Thinyounyong, W. & Thavorncharoensap, M., 2018, In : Expert review of pharmacoeconomics & outcomes research. 18, p. 215-222 8 p.Research output: Contribution to journal › Article › Academic › peer-review
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Health related quality of life impact from rotavirus diarrhea on children and their family caregivers in Thailand. / Rochanathimoke, Onwipa; Riewpaiboon, Arthorn; Postma, Maarten J; Thinyounyong, Wirawan; Thavorncharoensap, Montarat.
In: Expert review of pharmacoeconomics & outcomes research, Vol. 18, 2018, p. 215-222.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - Health related quality of life impact from rotavirus diarrhea on children and their family caregivers in Thailand
AU - Rochanathimoke, Onwipa
AU - Riewpaiboon, Arthorn
AU - Postma, Maarten J
AU - Thinyounyong, Wirawan
AU - Thavorncharoensap, Montarat
PY - 2018
Y1 - 2018
N2 - BACKGROUND: Rotavirus diarrhea is a major health problem among young children worldwide with potential negative impacts on health-related quality of life (HRQoL). This study assessed the impact of rotavirus diarrhea on HRQoL of children and their caregivers.METHODS: We performed a cross-sectional study among 460 hospitalized children with diarrhea aged under 5 years and their family caregivers at three hospitals in Phetchabun province, Thailand during May 2013 and February 2014. The severity of diarrhea was assessed using the Vesikari severity scoring system while the HRQoL was assessed using the EQ-5D-3L.RESULTS: The mean EQ-5D utility of children with all-causes diarrhea was 0.604. The utility of the rotavirus diarrhea group was significantly lower than that of the non-rotavirus diarrhea group (0.593 vs. 0.612; p-value = 0.040). The family caregiver's utility was 0.964 at baseline and significantly decreased to 0.620 (p-value = 0.041) when their children were hospitalized with diarrhea. In multiple regression analyses, severity but not rotavirus infection had significant negative impacts on the utility of both the children and their caregivers.CONCLUSION: Diarrhea, either caused by rotavirus or non-rotavirus infection, resulted in substantial negative impacts on the quality of life of both the children and their caregivers.
AB - BACKGROUND: Rotavirus diarrhea is a major health problem among young children worldwide with potential negative impacts on health-related quality of life (HRQoL). This study assessed the impact of rotavirus diarrhea on HRQoL of children and their caregivers.METHODS: We performed a cross-sectional study among 460 hospitalized children with diarrhea aged under 5 years and their family caregivers at three hospitals in Phetchabun province, Thailand during May 2013 and February 2014. The severity of diarrhea was assessed using the Vesikari severity scoring system while the HRQoL was assessed using the EQ-5D-3L.RESULTS: The mean EQ-5D utility of children with all-causes diarrhea was 0.604. The utility of the rotavirus diarrhea group was significantly lower than that of the non-rotavirus diarrhea group (0.593 vs. 0.612; p-value = 0.040). The family caregiver's utility was 0.964 at baseline and significantly decreased to 0.620 (p-value = 0.041) when their children were hospitalized with diarrhea. In multiple regression analyses, severity but not rotavirus infection had significant negative impacts on the utility of both the children and their caregivers.CONCLUSION: Diarrhea, either caused by rotavirus or non-rotavirus infection, resulted in substantial negative impacts on the quality of life of both the children and their caregivers.
KW - Journal Article
KW - SCORES
KW - UK
KW - ACUTE GASTROENTERITIS
KW - UTILITY
KW - BURDEN
KW - EPIDEMIOLOGY
KW - EQ-5D
KW - INFECTIONS
KW - MORTALITY
KW - INFANTS
U2 - 10.1080/14737167.2018.1386561
DO - 10.1080/14737167.2018.1386561
M3 - Article
C2 - 28984150
VL - 18
SP - 215
EP - 222
JO - Expert Review of Pharmacoeconomics and Outcomes Research
JF - Expert Review of Pharmacoeconomics and Outcomes Research
SN - 1473-7167
ER -
ID: 48959876