Publication

Hallmarks of Cellular Senescence

Hernandez-Segura, A., Nehme, J. & Demaria, M., Jun-2018, In : Trends in Cell Biology. 28, 6, p. 436-453 18 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018). Hallmarks of Cellular Senescence. Trends in Cell Biology, 28(6), 436-453. https://doi.org/10.1016/j.tcb.2018.02.001

Author

Hernandez-Segura, Alejandra ; Nehme, Jamil ; Demaria, Marco. / Hallmarks of Cellular Senescence. In: Trends in Cell Biology. 2018 ; Vol. 28, No. 6. pp. 436-453.

Harvard

Hernandez-Segura, A, Nehme, J & Demaria, M 2018, 'Hallmarks of Cellular Senescence', Trends in Cell Biology, vol. 28, no. 6, pp. 436-453. https://doi.org/10.1016/j.tcb.2018.02.001

Standard

Hallmarks of Cellular Senescence. / Hernandez-Segura, Alejandra; Nehme, Jamil; Demaria, Marco.

In: Trends in Cell Biology, Vol. 28, No. 6, 06.2018, p. 436-453.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Hernandez-Segura A, Nehme J, Demaria M. Hallmarks of Cellular Senescence. Trends in Cell Biology. 2018 Jun;28(6):436-453. https://doi.org/10.1016/j.tcb.2018.02.001


BibTeX

@article{ec04739dd2f54252b0a4e8a59352d8bb,
title = "Hallmarks of Cellular Senescence",
abstract = "Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential and function of tissues, to inflammation, and to tumorigenesis in aged organisms. Therefore, the identification, characterization, and pharmacological elimination of senescent cells have gained attention in the field of aging research. However, the nonspecificity of current senescence markers and the existence of different senescence programs strongly limit these tasks. Here, we describe the molecular regulators of senescence phenotypes and how they are used for identifying senescent cells in vitro and in vivo. We also highlight the importance that these levels of regulations have in the development of therapeutic targets.",
keywords = "ONCOGENE-INDUCED SENESCENCE, DNA-DAMAGE RESPONSE, LYSOSOMAL BETA-GALACTOSIDASE, HUMAN-DIPLOID FIBROBLASTS, TUMOR-SUPPRESSOR GENE, SECRETORY PHENOTYPE, OXIDATIVE STRESS, MITOCHONDRIAL DYSFUNCTION, PREMATURE SENESCENCE, TRANSCRIPTIONAL REGULATION",
author = "Alejandra Hernandez-Segura and Jamil Nehme and Marco Demaria",
note = "Copyright {\circledC} 2018 Elsevier Ltd. All rights reserved.",
year = "2018",
month = "6",
doi = "10.1016/j.tcb.2018.02.001",
language = "English",
volume = "28",
pages = "436--453",
journal = "Trends in Cell Biology",
issn = "0962-8924",
publisher = "ELSEVIER SCIENCE LONDON",
number = "6",

}

RIS

TY - JOUR

T1 - Hallmarks of Cellular Senescence

AU - Hernandez-Segura, Alejandra

AU - Nehme, Jamil

AU - Demaria, Marco

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018/6

Y1 - 2018/6

N2 - Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential and function of tissues, to inflammation, and to tumorigenesis in aged organisms. Therefore, the identification, characterization, and pharmacological elimination of senescent cells have gained attention in the field of aging research. However, the nonspecificity of current senescence markers and the existence of different senescence programs strongly limit these tasks. Here, we describe the molecular regulators of senescence phenotypes and how they are used for identifying senescent cells in vitro and in vivo. We also highlight the importance that these levels of regulations have in the development of therapeutic targets.

AB - Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential and function of tissues, to inflammation, and to tumorigenesis in aged organisms. Therefore, the identification, characterization, and pharmacological elimination of senescent cells have gained attention in the field of aging research. However, the nonspecificity of current senescence markers and the existence of different senescence programs strongly limit these tasks. Here, we describe the molecular regulators of senescence phenotypes and how they are used for identifying senescent cells in vitro and in vivo. We also highlight the importance that these levels of regulations have in the development of therapeutic targets.

KW - ONCOGENE-INDUCED SENESCENCE

KW - DNA-DAMAGE RESPONSE

KW - LYSOSOMAL BETA-GALACTOSIDASE

KW - HUMAN-DIPLOID FIBROBLASTS

KW - TUMOR-SUPPRESSOR GENE

KW - SECRETORY PHENOTYPE

KW - OXIDATIVE STRESS

KW - MITOCHONDRIAL DYSFUNCTION

KW - PREMATURE SENESCENCE

KW - TRANSCRIPTIONAL REGULATION

U2 - 10.1016/j.tcb.2018.02.001

DO - 10.1016/j.tcb.2018.02.001

M3 - Review article

VL - 28

SP - 436

EP - 453

JO - Trends in Cell Biology

JF - Trends in Cell Biology

SN - 0962-8924

IS - 6

ER -

ID: 54867008