Publication

Hallmarks of Cellular Senescence

Hernandez-Segura, A., Nehme, J. & Demaria, M., Jun-2018, In : Trends in Cell Biology. 28, 6, p. 436-453 18 p.

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  • Hallmarks of Cellular Senescence

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DOI

Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential and function of tissues, to inflammation, and to tumorigenesis in aged organisms. Therefore, the identification, characterization, and pharmacological elimination of senescent cells have gained attention in the field of aging research. However, the nonspecificity of current senescence markers and the existence of different senescence programs strongly limit these tasks. Here, we describe the molecular regulators of senescence phenotypes and how they are used for identifying senescent cells in vitro and in vivo. We also highlight the importance that these levels of regulations have in the development of therapeutic targets.

Original languageEnglish
Pages (from-to)436-453
Number of pages18
JournalTrends in Cell Biology
Volume28
Issue number6
Early online date21-Feb-2018
Publication statusPublished - Jun-2018

    Keywords

  • ONCOGENE-INDUCED SENESCENCE, DNA-DAMAGE RESPONSE, LYSOSOMAL BETA-GALACTOSIDASE, HUMAN-DIPLOID FIBROBLASTS, TUMOR-SUPPRESSOR GENE, SECRETORY PHENOTYPE, OXIDATIVE STRESS, MITOCHONDRIAL DYSFUNCTION, PREMATURE SENESCENCE, TRANSCRIPTIONAL REGULATION

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