Publication
Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome
Vich Vila, A., Imhann, F., Collij, V., Jankipersadsing, S. A., Gurry, T., Mujagic, Z., Kurilshikov, A., Bonder, M. J., Jiang, X., Tigchelaar, E. F., Dekens, J., Peters, V., Voskuil, M. D., Visschedijk, M. C., van Dullemen, H. M., Keszthelyi, D., Swertz, M. A., Franke, L., Alberts, R., Festen, E. A. M., Dijkstra, G., Masclee, A. A. M., Hofker, M. H., Xavier, R. J., Alm, E. J., Fu, J., Wijmenga, C., Jonkers, D. M. A. E., Zhernakova, A. & Weersma, R. K., 19-Dec-2018, In : Science Translational Medicine. 10, 472, 12 p.Research output: Contribution to journal › Article › Academic › peer-review

Documents
- Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome
Final publisher's version, 1.43 MB, PDF document
Links
- https://www.rug.nl/research/portal/files/102587986/Chapter_3.pdf
Final author's version
DOI
Changes in the gut microbiota have been associated with two of the most common gastrointestinal diseases, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Here, we performed a case-control analysis using shotgun metagenomic sequencing of stool samples from 1792 individuals with IBD and IBS compared with control individuals in the general population. Despite substantial overlap between the gut microbiome of patients with IBD and IBS compared with control individuals, we were able to use gut microbiota composition differences to distinguish patients with IBD from those with IBS. By combining species-level profiles and strain-level profiles with bacterial growth rates, metabolic functions, antibiotic resistance, and virulence factor analyses, we identified key bacterial species that may be involved in two common gastrointestinal diseases.
Original language | English |
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Number of pages | 12 |
Journal | Science Translational Medicine |
Volume | 10 |
Issue number | 472 |
Publication status | Published - 19-Dec-2018 |
- MARKERS, IRON, RESISTANCE, IDENTIFICATION, INTESTINE, ALIGNMENT
Keywords
ID: 72646794