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Guidelines for genomic array analysis in acquired haematological neoplastic disorders

Schoumans, J., Suela, J., Hastings, R., Muehlematter, D., Rack, K., van den Berg, E., Beverloo, H. B. & Stevens-Kroef, M., May-2016, In : GENES CHROMOSOMES & CANCER. 55, 5, p. 480-491 12 p.

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  • Guidelines for genomic array analysis in acquired haematological neoplastic disorders

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DOI

  • Jacqueline Schoumans
  • Javier Suela
  • Ros Hastings
  • Dominique Muehlematter
  • Katrina Rack
  • Eva van den Berg
  • H. Berna Beverloo
  • Marian Stevens-Kroef

Genetic profiling is important for disease evaluation and prediction of prognosis or responsiveness to therapy in neoplasia. Microarray technologies, including array comparative genomic hybridization and single-nucleotide polymorphism-detecting arrays, have in recent years been introduced into the diagnostic setting for specific types of haematological malignancies and solid tumours. It can be used as a complementary test or depending on the neoplasia investigated, also as a standalone test. However, comprehensive and readable presentation of frequently identified complex genomic profiles remains challenging. To assist diagnostic laboratories, standardization and minimum criteria for clinical interpretation and reporting of acquired genomic abnormalities detected through arrays in neoplastic disorders are presented. (c) 2016 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)480-491
Number of pages12
JournalGENES CHROMOSOMES & CANCER
Volume55
Issue number5
Publication statusPublished - May-2016

    Keywords

  • CHRONIC LYMPHOCYTIC-LEUKEMIA, ACUTE LYMPHOBLASTIC-LEUKEMIA, B-CELL PRECURSOR, COPY NUMBER ABNORMALITIES, MULTIPLE-MYELOMA, MYELODYSPLASTIC SYNDROMES, PROGNOSTIC-SIGNIFICANCE, MICROARRAY ANALYSIS, IKZF1 DELETION, CHROMOSOME-ABNORMALITIES

ID: 40972385