Guidelines and recommendations on yeast cell death nomenclature

Carmona-Gutierrez, D., Bauer, M. A., Zimmermann, A., Aguilera, A., Austriaco, N., Ayscough, K., Balzan, R., Bar-Nun, S., Barrientos, A., Belenky, P., Blondel, M., Braun, R. J., Breitenbach, M., Burhans, W. C., Büttner, S., Cavalieri, D., Chang, M., Cooper, K. F., Côrte-Real, M., Costa, V., Cullin, C., Dawes, I., Dengjel, J., Dickman, M. B., Eisenberg, T., Fahrenkrog, B., Fasel, N., Fröhlich, K-U., Gargouri, A., Giannattasio, S., Goffrini, P., Gourlay, C. W., Grant, C. M., Greenwood, M. T., Guaragnella, N., Heger, T., Heinisch, J., Herker, E., Herrmann, J. M., Hofer, S., Jiménez-Ruiz, A., Jungwirth, H., Kainz, K., Kontoyiannis, D. P., Ludovico, P., Manon, S., Martegani, E., Mazzoni, C., Megeney, L. A., Meisinger, C., Nielsen, J., Nyström, T., Osiewacz, H. D., Outeiro, T. F., Park, H-O., Pendl, T., Petranovic, D., Picot, S., Polčic, P., Powers, T., Ramsdale, M., Rinnerthaler, M., Rockenfeller, P., Ruckenstuhl, C., Schaffrath, R., Segovia, M., Severin, F. F., Sharon, A., Sigrist, S. J., Sommer-Ruck, C., Sousa, M. J., Thevelein, J. M., Thevissen, K., Titorenko, V., Toledano, M. B., Tuite, M., Vögtle, F-N., Westermann, B., Winderickx, J., Wissing, S., Wölfl, S., Zhang, Z. J., Zhao, R. Y., Zhou, B., Galluzzi, L., Kroemer, G. & Madeo, F., 1-Jan-2018, In : Microbial Cell. 5, 1, p. 4-31 28 p.

Research output: Contribution to journalReview articleAcademicpeer-review

  • Didac Carmona-Gutierrez
  • Maria Anna Bauer
  • Andreas Zimmermann
  • Andrés Aguilera
  • Nicanor Austriaco
  • Kathryn Ayscough
  • Rena Balzan
  • Shoshana Bar-Nun
  • Antonio Barrientos
  • Peter Belenky
  • Marc Blondel
  • Ralf J Braun
  • Michael Breitenbach
  • William C Burhans
  • Sabrina Büttner
  • Duccio Cavalieri
  • Michael Chang
  • Katrina F Cooper
  • Manuela Côrte-Real
  • Vítor Costa
  • Christophe Cullin
  • Ian Dawes
  • Jörn Dengjel
  • Martin B Dickman
  • Tobias Eisenberg
  • Birthe Fahrenkrog
  • Nicolas Fasel
  • Kai-Uwe Fröhlich
  • Ali Gargouri
  • Sergio Giannattasio
  • Paola Goffrini
  • Campbell W Gourlay
  • Chris M Grant
  • Michael T Greenwood
  • Nicoletta Guaragnella
  • Thomas Heger
  • Jürgen Heinisch
  • Eva Herker
  • Johannes M Herrmann
  • Sebastian Hofer
  • Antonio Jiménez-Ruiz
  • Helmut Jungwirth
  • Katharina Kainz
  • Dimitrios P Kontoyiannis
  • Paula Ludovico
  • Stéphen Manon
  • Enzo Martegani
  • Cristina Mazzoni
  • Lynn A Megeney
  • Chris Meisinger
  • Jens Nielsen
  • Thomas Nyström
  • Heinz D Osiewacz
  • Tiago F Outeiro
  • Hay-Oak Park
  • Tobias Pendl
  • Dina Petranovic
  • Stephane Picot
  • Peter Polčic
  • Ted Powers
  • Mark Ramsdale
  • Mark Rinnerthaler
  • Patrick Rockenfeller
  • Christoph Ruckenstuhl
  • Raffael Schaffrath
  • Maria Segovia
  • Fedor F Severin
  • Amir Sharon
  • Stephan J Sigrist
  • Cornelia Sommer-Ruck
  • Maria João Sousa
  • Johan M Thevelein
  • Karin Thevissen
  • Vladimir Titorenko
  • Michel B Toledano
  • Mick Tuite
  • F-Nora Vögtle
  • Benedikt Westermann
  • Joris Winderickx
  • Silke Wissing
  • Stefan Wölfl
  • Zhaojie J Zhang
  • Richard Y Zhao
  • Bing Zhou
  • Lorenzo Galluzzi
  • Guido Kroemer
  • Frank Madeo

Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cel-lular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the defi-nition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria. Specifically, we provide consensus guidelines on the differ-ential definition of terms including apoptosis, regulated necrosis, and autophagic cell death, as we refer to additional cell death rou-tines that are relevant for the biology of (at least some species of) yeast. As this area of investigation advances rapidly, changes and extensions to this set of recommendations will be implemented in the years to come. Nonetheless, we strongly encourage the au-thors, reviewers and editors of scientific articles to adopt these collective standards in order to establish an accurate framework for yeast cell death research and, ultimately, to accelerate the pro-gress of this vibrant field of research.

Original languageEnglish
Pages (from-to)4-31
Number of pages28
JournalMicrobial Cell
Issue number1
Publication statusPublished - 1-Jan-2018


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