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Granulosa cell tumors of the ovary: The clinical value of serum inhibin A and B levels in a large single center cohort

Mom, C. H., Engelen, M. J. A., Willemse, P. H. B., Gietema, J. A., ten Hoor, K. A., de Vries, E. G. E. & van der Zee, A. G. J., May-2007, In : Gynecologic Oncology. 105, 2, p. 365-372 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Objectives. In patients with a granulosa cell tumor of the ovary, the value of serum inhibin A and B concentrations for the assessment of disease status was investigated.

Methods. In 30 consecutive patients with a stage I-III granulosa cell tumor, inhibin A and B concentrations were measured in pre- and post-treatment serum samples. Clinical data concerning diagnosis, treatment and follow-up of these patients were related to serum inhibin A and B concentrations. Serum samples from 41 premenopausal females with cervical dysplasia, served as controls.

Results. In 30 patients, 13 (43%) recurrences were observed during a median follow-up of 10 years (range 1-31 years). Serum inhibin A and B concentrations were elevated in respectively 67% and 89% of the patients at diagnosis, and in 58% and 85% at recurrence. Inhibin A and B concentrations were normal in all controls. Sensitivity of inhibin A testing for the diagnosis of granulosa cell tumor was 67% with a specificity of 100%, compared to 89% and 100% respectively for inhibin B (ns). Elevations in serum inhibin B concentrations predated recurrences by a median of 11 months. None of the patients in remission showed increased concentrations of inhibin A and B.

Conclusion. Inhibin B seems to be the predominant form of inhibin secreted by granulosa cell tumors and appears to reflect disease status more accurately than inhibin A. Measurement of serum inhibin B concentrations may be preferred for the follow-up of granulosa cell tumors. (c) 2007 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)365-372
Number of pages8
JournalGynecologic Oncology
Volume105
Issue number2
Publication statusPublished - May-2007

    Keywords

  • granulosa cell tumor, inhibin A, inhibin B, tumor marker, sex-cord stromal tumor, HUMAN MENSTRUAL-CYCLE, POSTMENOPAUSAL WOMEN, INITIAL DIAGNOSIS, FOLLICULAR-FLUID, MARKER, CANCER, INHIBIN/ACTIVIN, SUBSTANCE, ESTRADIOL, HORMONE

ID: 4559218