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Gold(I) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro

Serratice, M., Bertrand, B., Janssen, E. F. J., Hemelt, E., Zucca, A., Cocco, F., Cinellu, M. A. & Casini, A., Sep-2014, In : MedChemComm. 5, 9, p. 1418-1422 5 p.

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  • Gold(I) compounds with lansoprazole-type ligands synthesis, characterization and anticancer

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DOI

  • M. Serratice
  • B. Bertrand
  • E. F. J. Janssen
  • E. Hemelt
  • A. Zucca
  • F. Cocco
  • M. A. Cinellu
  • A. Casini

A number of gold(I) complexes containing the proton pump inhibitor (PPI) lansoprazole and its reduced precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methylthio)-1H-benzo[d]imidazole have been synthesized and their biological effects have been evaluated in human cancer and nontumorigenic cells in vitro. The lansoprazole-based compounds appear to act through a V-H+-ATPase-mediated mechanism.

Original languageEnglish
Pages (from-to)1418-1422
Number of pages5
JournalMedChemComm
Volume5
Issue number9
Publication statusPublished - Sep-2014

    Keywords

  • PROTON-PUMP INHIBITORS, ANTIPROLIFERATIVE PROPERTIES, SOLUTION BEHAVIOR, COMPLEXES, RESISTANCE, CHEMISTRY, TARGETS, SERIES, AGENTS, TUMORS

ID: 15711214