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Glycoconjugates via Phosphorus Ylides

Ghonchepour, E., Neochoritis, C. G., Kurpiewska, K., Kalinowska-Tluscik, J., Islami, M. R. & Domling, A., 16-Jun-2019, In : European Journal of Organic Chemistry. 2019, 22, p. 3632-3635 4 p.

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  • Glycoconjugates via Phosphorus Ylides

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DOI

  • Ehsan Ghonchepour
  • Constantinos G. Neochoritis
  • Katarzyna Kurpiewska
  • Justyna Kalinowska-Tluscik
  • Mohammad R. Islami
  • Alexander Domling

A facile, high yielding access to rare chimeric compounds combining phosphorus ylides with complex glycosyl formamides is described. We determined X-ray structures gaining structural insight into this compounds class. In addition, data mining of similar compounds deposited within the Cambridge Structural Database was performed. These derivatives could be used either as synthetic intermediates via the ylide functionalization and glyco chemical biology synthons or improving the pharmacokinetic properties of a potential bioactive molecule, exploiting the glycosyl moiety.

Original languageEnglish
Pages (from-to)3632-3635
Number of pages4
JournalEuropean Journal of Organic Chemistry
Volume2019
Issue number22
Publication statusPublished - 16-Jun-2019

    Keywords

  • Phosphorus Ylides, Glycoconjugates, Glycosyl Formamides, Multi-Component Reactions, Chemical Biology, ONE-POT SYNTHESIS, ACETYLENIC ESTERS, DIMETHYL ACETYLENEDICARBOXYLATE, 3-COMPONENT REACTION, VINYLPHOSPHONIUM SALTS, TRIPHENYLPHOSPHINE, EFFICIENT, FACILE

ID: 118505275