Publication

Getting up to speed with transcription elongation by RNA polymerase II

Jonkers, I. & Lis, J. T., Mar-2015, In : Nature Reviews Molecular Cell Biology. 16, 3, p. 167-177 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Recent advances in sequencing techniques that measure nascent transcripts and that reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in promoter-proximal regions and its release to initiate a phase of productive elongation are key steps in transcription regulation. Moreover, after the release of Pol II from the promoter-proximal region, elongation rates are highly dynamic throughout the transcription of a gene, and vary on a gene-by-gene basis. Interestingly, Pol II elongation rates affect co-transcriptional processes such as splicing, termination and genome stability. Increasing numbers of factors and regulatory mechanisms have been associated with the steps of transcription elongation by Pol II, revealing that elongation is a highly complex process. Elongation is thus now recognized as a key phase in the regulation of transcription by Pol II.

Original languageEnglish
Pages (from-to)167-177
Number of pages11
JournalNature Reviews Molecular Cell Biology
Volume16
Issue number3
Publication statusPublished - Mar-2015

    Keywords

  • NF-KAPPA-B, EXON-INTRON STRUCTURE, IMMEDIATE-EARLY GENES, EMBRYONIC STEM-CELLS, P-TEFB, POL II, NASCENT-RNA, COMPLEX SEC, GAGA FACTOR, IN-VIVO

ID: 17469690