Publication

Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: A molecular-epidemiological analysis

Grundmann, H., Aanensen, D. M., van den Wijngaard, C. C., Spratt, B. G., Harmsen, D., Friedrich, A. W., European Staphylococcal Reference Laboratory Working Group & Tami, A., 12-Jan-2010, In : PLOS MEDICINE. 7, 1, 15 p., 1000215.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Grundmann, H., Aanensen, D. M., van den Wijngaard, C. C., Spratt, B. G., Harmsen, D., Friedrich, A. W., ... Tami, A. (2010). Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: A molecular-epidemiological analysis. PLOS MEDICINE, 7(1), [1000215]. https://doi.org/10.1371/journal.pmed.1000215

Author

Grundmann, Hajo ; Aanensen, David M ; van den Wijngaard, Cees C ; Spratt, Brian G ; Harmsen, Dag ; Friedrich, Alexander W ; European Staphylococcal Reference Laboratory Working Group ; Tami, Adriana. / Geographic distribution of Staphylococcus aureus causing invasive infections in Europe : A molecular-epidemiological analysis. In: PLOS MEDICINE. 2010 ; Vol. 7, No. 1.

Harvard

Grundmann, H, Aanensen, DM, van den Wijngaard, CC, Spratt, BG, Harmsen, D, Friedrich, AW, European Staphylococcal Reference Laboratory Working Group & Tami, A 2010, 'Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: A molecular-epidemiological analysis', PLOS MEDICINE, vol. 7, no. 1, 1000215. https://doi.org/10.1371/journal.pmed.1000215

Standard

Geographic distribution of Staphylococcus aureus causing invasive infections in Europe : A molecular-epidemiological analysis. / Grundmann, Hajo; Aanensen, David M; van den Wijngaard, Cees C; Spratt, Brian G; Harmsen, Dag; Friedrich, Alexander W; European Staphylococcal Reference Laboratory Working Group ; Tami, Adriana.

In: PLOS MEDICINE, Vol. 7, No. 1, 1000215, 12.01.2010.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Grundmann H, Aanensen DM, van den Wijngaard CC, Spratt BG, Harmsen D, Friedrich AW et al. Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: A molecular-epidemiological analysis. PLOS MEDICINE. 2010 Jan 12;7(1). 1000215. https://doi.org/10.1371/journal.pmed.1000215


BibTeX

@article{c2d42546ff1a4d5e81257f435d8fc889,
title = "Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: A molecular-epidemiological analysis",
abstract = "Background: Staphylococcus aureus is one of the most important human pathogens and methicillin-resistant variants (MRSAs) are a major cause of hospital and community-acquired infection. We aimed to map the geographic distribution of the dominant clones that cause invasive infections in Europe.Methods and Findings: In each country, staphylococcal reference laboratories secured the participation of a sufficient number of hospital laboratories to achieve national geo-demographic representation. Participating laboratories collected successive methicillin-susceptible (MSSA) and MRSA isolates from patients with invasive S. aureus infection using an agreed protocol. All isolates were sent to the respective national reference laboratories and characterised by quality-controlled sequence typing of the variable region of the staphylococcal spa gene (spa typing), and data were uploaded to a central database. Relevant genetic and phenotypic information was assembled for interactive interrogation by a purpose-built Web-based mapping application. Between September 2006 and February 2007, 357 laboratories serving 450 hospitals in 26 countries collected 2,890 MSSA and MRSA isolates from patients with invasive S. aureus infection. A wide geographical distribution of spa types was found with some prevalent in all European countries. MSSA were more diverse than MRSA. Genetic diversity of MRSA differed considerably between countries with dominant MRSA spa types forming distinctive geographical clusters. We provide evidence that a network approach consisting of decentralised typing and visualisation of aggregated data using an interactive mapping tool can provide important information on the dynamics of MRSA populations such as early signalling of emerging strains, cross border spread, and importation by travel.Conclusions: In contrast to MSSA, MRSA spa types have a predominantly regional distribution in Europe. This finding is indicative of the selection and spread of a limited number of clones within health care networks, suggesting that control efforts aimed at interrupting the spread within and between health care institutions may not only be feasible but ultimately successful and should therefore be strongly encouraged.",
keywords = "GENE, BACTEREMIA, COMMUNITY, SOFTWARE, MRSA",
author = "Hajo Grundmann and Aanensen, {David M} and {van den Wijngaard}, {Cees C} and Spratt, {Brian G} and Dag Harmsen and Friedrich, {Alexander W} and {European Staphylococcal Reference Laboratory Working Group} and Adriana Tami",
year = "2010",
month = "1",
day = "12",
doi = "10.1371/journal.pmed.1000215",
language = "English",
volume = "7",
journal = "PLOS MEDICINE",
issn = "1549-1277",
publisher = "PUBLIC LIBRARY SCIENCE",
number = "1",

}

RIS

TY - JOUR

T1 - Geographic distribution of Staphylococcus aureus causing invasive infections in Europe

T2 - A molecular-epidemiological analysis

AU - Grundmann, Hajo

AU - Aanensen, David M

AU - van den Wijngaard, Cees C

AU - Spratt, Brian G

AU - Harmsen, Dag

AU - Friedrich, Alexander W

AU - European Staphylococcal Reference Laboratory Working Group

AU - Tami, Adriana

PY - 2010/1/12

Y1 - 2010/1/12

N2 - Background: Staphylococcus aureus is one of the most important human pathogens and methicillin-resistant variants (MRSAs) are a major cause of hospital and community-acquired infection. We aimed to map the geographic distribution of the dominant clones that cause invasive infections in Europe.Methods and Findings: In each country, staphylococcal reference laboratories secured the participation of a sufficient number of hospital laboratories to achieve national geo-demographic representation. Participating laboratories collected successive methicillin-susceptible (MSSA) and MRSA isolates from patients with invasive S. aureus infection using an agreed protocol. All isolates were sent to the respective national reference laboratories and characterised by quality-controlled sequence typing of the variable region of the staphylococcal spa gene (spa typing), and data were uploaded to a central database. Relevant genetic and phenotypic information was assembled for interactive interrogation by a purpose-built Web-based mapping application. Between September 2006 and February 2007, 357 laboratories serving 450 hospitals in 26 countries collected 2,890 MSSA and MRSA isolates from patients with invasive S. aureus infection. A wide geographical distribution of spa types was found with some prevalent in all European countries. MSSA were more diverse than MRSA. Genetic diversity of MRSA differed considerably between countries with dominant MRSA spa types forming distinctive geographical clusters. We provide evidence that a network approach consisting of decentralised typing and visualisation of aggregated data using an interactive mapping tool can provide important information on the dynamics of MRSA populations such as early signalling of emerging strains, cross border spread, and importation by travel.Conclusions: In contrast to MSSA, MRSA spa types have a predominantly regional distribution in Europe. This finding is indicative of the selection and spread of a limited number of clones within health care networks, suggesting that control efforts aimed at interrupting the spread within and between health care institutions may not only be feasible but ultimately successful and should therefore be strongly encouraged.

AB - Background: Staphylococcus aureus is one of the most important human pathogens and methicillin-resistant variants (MRSAs) are a major cause of hospital and community-acquired infection. We aimed to map the geographic distribution of the dominant clones that cause invasive infections in Europe.Methods and Findings: In each country, staphylococcal reference laboratories secured the participation of a sufficient number of hospital laboratories to achieve national geo-demographic representation. Participating laboratories collected successive methicillin-susceptible (MSSA) and MRSA isolates from patients with invasive S. aureus infection using an agreed protocol. All isolates were sent to the respective national reference laboratories and characterised by quality-controlled sequence typing of the variable region of the staphylococcal spa gene (spa typing), and data were uploaded to a central database. Relevant genetic and phenotypic information was assembled for interactive interrogation by a purpose-built Web-based mapping application. Between September 2006 and February 2007, 357 laboratories serving 450 hospitals in 26 countries collected 2,890 MSSA and MRSA isolates from patients with invasive S. aureus infection. A wide geographical distribution of spa types was found with some prevalent in all European countries. MSSA were more diverse than MRSA. Genetic diversity of MRSA differed considerably between countries with dominant MRSA spa types forming distinctive geographical clusters. We provide evidence that a network approach consisting of decentralised typing and visualisation of aggregated data using an interactive mapping tool can provide important information on the dynamics of MRSA populations such as early signalling of emerging strains, cross border spread, and importation by travel.Conclusions: In contrast to MSSA, MRSA spa types have a predominantly regional distribution in Europe. This finding is indicative of the selection and spread of a limited number of clones within health care networks, suggesting that control efforts aimed at interrupting the spread within and between health care institutions may not only be feasible but ultimately successful and should therefore be strongly encouraged.

KW - GENE

KW - BACTEREMIA

KW - COMMUNITY

KW - SOFTWARE

KW - MRSA

U2 - 10.1371/journal.pmed.1000215

DO - 10.1371/journal.pmed.1000215

M3 - Article

VL - 7

JO - PLOS MEDICINE

JF - PLOS MEDICINE

SN - 1549-1277

IS - 1

M1 - 1000215

ER -

ID: 5023104