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Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

Graff, M., Scott, R. A., Justice, A. E., Young, K. L., Feitosa, M. F., Barata, L., Winkler, T. W., Chu, A. Y., Mahajan, A., Hadley, D., Xue, L., Workalemahu, T., Heard-Costa, N. L., den Hoed, M., Ahluwalia, T. S., Qi, Q., Ngwa, J. S., Renstrom, F., Quaye, L., Eicher, J. D., Hayes, J. E., Cornelis, M., Kutalik, Z., Lim, E., Luan, J., Huffman, J. E., Zhang, W., Zhao, W., Griffin, P. J., Haller, T., Ahmad, S., Marques-Vidal, P. M., Bien, S., Yengo, L., Teumer, A., Smith, A. V., Kumari, M., Harder, M. N., Justesen, J. M., Kleber, M. E., Hollensted, M., Lohman, K., Rivera, N. V., Whitfield, J. B., Van der Most, P. J., Nolte, I. M., Oldehinkel, A. J., Snieder, H., van Vliet-Ostaptchouk, J. V., Hartman, C. A., CHARGE Consortium, EPIC-InterAct Consortium & PAGE Consortium, 27-Apr-2017, In : PLoS genetics. 13, 4, 26 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Mariaelisa Graff
  • Robert A. Scott
  • Anne E. Justice
  • Kristin L. Young
  • Mary F. Feitosa
  • Llilda Barata
  • Thomas W. Winkler
  • Audrey Y. Chu
  • Anubha Mahajan
  • David Hadley
  • Luting Xue
  • Tsegaselassie Workalemahu
  • Nancy L. Heard-Costa
  • Marcel den Hoed
  • Tarunveer S. Ahluwalia
  • Qibin Qi
  • Julius S. Ngwa
  • Frida Renstrom
  • Lydia Quaye
  • John D. Eicher
  • James E. Hayes
  • Marilyn Cornelis
  • Zoltan Kutalik
  • Elise Lim
  • Jian'an Luan
  • Jennifer E. Huffman
  • Weihua Zhang
  • Wei Zhao
  • Paula J. Griffin
  • Toomas Haller
  • Shafqat Ahmad
  • Pedro M. Marques-Vidal
  • Stephanie Bien
  • Loic Yengo
  • Alexander Teumer
  • Albert Vernon Smith
  • Meena Kumari
  • Marie Neergaard Harder
  • Johanne Marie Justesen
  • Marcus E. Kleber
  • Mette Hollensted
  • Kurt Lohman
  • Natalia V. Rivera
  • John B. Whitfield
  • Peter J. Van der Most
  • Ilja M. Nolte
  • Albertine J. Oldehinkel
  • Harold Snieder
  • Jana V. van Vliet-Ostaptchouk
  • Catharina A. Hartman
  • CHARGE Consortium
  • EPIC-InterAct Consortium
  • PAGE Consortium

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by similar to 30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

Original languageEnglish
Number of pages26
JournalPLoS genetics
Volume13
Issue number4
Publication statusPublished - 27-Apr-2017

    Keywords

  • BODY-MASS INDEX, REACTIVE PROTEIN-LEVELS, GENE-EXPRESSION, IDENTICAL-TWINS, ADIPOCYTE DIFFERENTIATION, ASSOCIATION METAANALYSIS, ACTIVITY QUESTIONNAIRES, FAT DISTRIBUTION, BINDING PROTEIN, FOOD-INTAKE
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  1. Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

    Graff, M., Scott, R. A., Justice, A. E., Young, K. L., Feitosa, M. F., Barata, L., Winkler, T. W., Chu, A. Y., Mahajan, A., Hadley, D., Xue, L., Workalemahu, T., Heard-Costa, N. L., den Hoed, M., Ahluwalia, T. S., Qi, Q., Ngwa, J. S., Renström, F., Quaye, L., Eicher, J. D., Hayes, J. E., Cornelis, M., Kutalik, Z., Lim, E., Luan, J., Huffman, J. E., Zhang, W., Zhao, W., Griffin, P. J., Haller, T., Ahmad, S., Marques-Vidal, P. M., Bien, S., Yengo, L., Teumer, A., Smith, A. V., Kumari, M., Harder, M. N., Justesen, J. M., Kleber, M. E., Zhao, J. H., Wu, Y., van der Most, P. J., Nolte, I. M., Oldehinkel, A. J., Sanna, S., Snieder, H., van Vliet-Ostaptchouk, J. V., Hartman, C. A., Penninx, B. W. J. H. & CHARGE Consortium, Aug-2017, In : PLoS genetics. 13, 8, 1 p., e1006972.

    Research output: Contribution to journalArticleAcademicpeer-review

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