Publication

Genetics, Lifestyle, and Low-Density Lipoprotein Cholesterol in Young and Apparently Healthy Women

Balder, J-W., Rimbert, A., Zhang, X., Viel, M., Kanninga, R., van Dijk, F., Lansberg, P., Sinke, R. & Kuivenhoven, J. A., 20-Feb-2018, In : Circulation. 137, 8, p. 820-831 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Balder, J-W., Rimbert, A., Zhang, X., Viel, M., Kanninga, R., van Dijk, F., ... Kuivenhoven, J. A. (2018). Genetics, Lifestyle, and Low-Density Lipoprotein Cholesterol in Young and Apparently Healthy Women. Circulation, 137(8), 820-831. https://doi.org/10.1161/CIRCULATIONAHA.117.032479

Author

Balder, Jan-Willem ; Rimbert, Antoine ; Zhang, Xiang ; Viel, Martijn ; Kanninga, Roan ; van Dijk, Freerk ; Lansberg, Peter ; Sinke, Richard ; Kuivenhoven, Jan Albert. / Genetics, Lifestyle, and Low-Density Lipoprotein Cholesterol in Young and Apparently Healthy Women. In: Circulation. 2018 ; Vol. 137, No. 8. pp. 820-831.

Harvard

Balder, J-W, Rimbert, A, Zhang, X, Viel, M, Kanninga, R, van Dijk, F, Lansberg, P, Sinke, R & Kuivenhoven, JA 2018, 'Genetics, Lifestyle, and Low-Density Lipoprotein Cholesterol in Young and Apparently Healthy Women', Circulation, vol. 137, no. 8, pp. 820-831. https://doi.org/10.1161/CIRCULATIONAHA.117.032479

Standard

Genetics, Lifestyle, and Low-Density Lipoprotein Cholesterol in Young and Apparently Healthy Women. / Balder, Jan-Willem; Rimbert, Antoine; Zhang, Xiang; Viel, Martijn; Kanninga, Roan; van Dijk, Freerk; Lansberg, Peter; Sinke, Richard; Kuivenhoven, Jan Albert.

In: Circulation, Vol. 137, No. 8, 20.02.2018, p. 820-831.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Balder J-W, Rimbert A, Zhang X, Viel M, Kanninga R, van Dijk F et al. Genetics, Lifestyle, and Low-Density Lipoprotein Cholesterol in Young and Apparently Healthy Women. Circulation. 2018 Feb 20;137(8):820-831. https://doi.org/10.1161/CIRCULATIONAHA.117.032479


BibTeX

@article{0c18fb7fa6c24b5c91bda1a61917e8f7,
title = "Genetics, Lifestyle, and Low-Density Lipoprotein Cholesterol in Young and Apparently Healthy Women",
abstract = "Background: Atherosclerosis starts in childhood but low-density lipoprotein cholesterol (LDL-C), a causal risk factor, is mostly studied and dealt with when clinical events have occurred. Women are usually affected later in life than men and are underdiagnosed, undertreated, and understudied in cardiovascular trials and research. This study aims at a better understanding of lifestyle and genetic factors that affect LDL-C in young women.Methods: We randomly selected for every year of age 8 women with LDL-C = 99th percentile (>= 186 mg/dL) from 28000 female participants aged between 25 to 40 years of a population-based cohort study. The resulting groups include 119 and 121 women, respectively, of an average 33 years of age. A gene-sequencing panel was used to assess established monogenic and polygenic origins of these phenotypes. Information on lifestyle was extracted from questionnaires. A healthy lifestyle score was allocated based on a recently developed algorithm.Results: Of the women with LDL-C = 99th percentile, 20 women (16.8{\%}) carried mutations that cause familial hypercholesterolemia, whereas 25 (21{\%}) were predisposed to high LDL-C on the basis of a high-weighted genetic risk score. The women in whom no genetic origin for hypercholesterolemia could be identified were found to exhibit a significantly unfavorable lifestyle in comparison with controls.Conclusions: This study highlights the need for early assessment of the cardiovascular risk profile in apparently healthy young women to identify those with LDL-C >= 99th percentile for their age: first, because, in this study, 17{\%} of the cases were molecularly diagnosed with familial hypercholesterolemia, which needs further attention; second, because our data indicate that an unfavorable lifestyle is significantly associated with severe hypercholesterolemia in genetically unaffected women, which may also need further attention.",
keywords = "DNA copy number variations, hypercholesterolemia, hypobetalipoproteinemias, lifestyle, lipids, lipoproteins, risk factors, CORONARY-HEART-DISEASE, FAMILIAL HYPERCHOLESTEROLEMIA, GENERAL-POPULATION, SEQUENCE VARIATION, LDL-CHOLESTEROL, UNITED-STATES, RISK, MUTATIONS, PARTICIPANTS, ASSOCIATION",
author = "Jan-Willem Balder and Antoine Rimbert and Xiang Zhang and Martijn Viel and Roan Kanninga and {van Dijk}, Freerk and Peter Lansberg and Richard Sinke and Kuivenhoven, {Jan Albert}",
note = "{\circledC} 2018 American Heart Association, Inc.",
year = "2018",
month = "2",
day = "20",
doi = "10.1161/CIRCULATIONAHA.117.032479",
language = "English",
volume = "137",
pages = "820--831",
journal = "Circulation",
issn = "0009-7322",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "8",

}

RIS

TY - JOUR

T1 - Genetics, Lifestyle, and Low-Density Lipoprotein Cholesterol in Young and Apparently Healthy Women

AU - Balder, Jan-Willem

AU - Rimbert, Antoine

AU - Zhang, Xiang

AU - Viel, Martijn

AU - Kanninga, Roan

AU - van Dijk, Freerk

AU - Lansberg, Peter

AU - Sinke, Richard

AU - Kuivenhoven, Jan Albert

N1 - © 2018 American Heart Association, Inc.

PY - 2018/2/20

Y1 - 2018/2/20

N2 - Background: Atherosclerosis starts in childhood but low-density lipoprotein cholesterol (LDL-C), a causal risk factor, is mostly studied and dealt with when clinical events have occurred. Women are usually affected later in life than men and are underdiagnosed, undertreated, and understudied in cardiovascular trials and research. This study aims at a better understanding of lifestyle and genetic factors that affect LDL-C in young women.Methods: We randomly selected for every year of age 8 women with LDL-C = 99th percentile (>= 186 mg/dL) from 28000 female participants aged between 25 to 40 years of a population-based cohort study. The resulting groups include 119 and 121 women, respectively, of an average 33 years of age. A gene-sequencing panel was used to assess established monogenic and polygenic origins of these phenotypes. Information on lifestyle was extracted from questionnaires. A healthy lifestyle score was allocated based on a recently developed algorithm.Results: Of the women with LDL-C = 99th percentile, 20 women (16.8%) carried mutations that cause familial hypercholesterolemia, whereas 25 (21%) were predisposed to high LDL-C on the basis of a high-weighted genetic risk score. The women in whom no genetic origin for hypercholesterolemia could be identified were found to exhibit a significantly unfavorable lifestyle in comparison with controls.Conclusions: This study highlights the need for early assessment of the cardiovascular risk profile in apparently healthy young women to identify those with LDL-C >= 99th percentile for their age: first, because, in this study, 17% of the cases were molecularly diagnosed with familial hypercholesterolemia, which needs further attention; second, because our data indicate that an unfavorable lifestyle is significantly associated with severe hypercholesterolemia in genetically unaffected women, which may also need further attention.

AB - Background: Atherosclerosis starts in childhood but low-density lipoprotein cholesterol (LDL-C), a causal risk factor, is mostly studied and dealt with when clinical events have occurred. Women are usually affected later in life than men and are underdiagnosed, undertreated, and understudied in cardiovascular trials and research. This study aims at a better understanding of lifestyle and genetic factors that affect LDL-C in young women.Methods: We randomly selected for every year of age 8 women with LDL-C = 99th percentile (>= 186 mg/dL) from 28000 female participants aged between 25 to 40 years of a population-based cohort study. The resulting groups include 119 and 121 women, respectively, of an average 33 years of age. A gene-sequencing panel was used to assess established monogenic and polygenic origins of these phenotypes. Information on lifestyle was extracted from questionnaires. A healthy lifestyle score was allocated based on a recently developed algorithm.Results: Of the women with LDL-C = 99th percentile, 20 women (16.8%) carried mutations that cause familial hypercholesterolemia, whereas 25 (21%) were predisposed to high LDL-C on the basis of a high-weighted genetic risk score. The women in whom no genetic origin for hypercholesterolemia could be identified were found to exhibit a significantly unfavorable lifestyle in comparison with controls.Conclusions: This study highlights the need for early assessment of the cardiovascular risk profile in apparently healthy young women to identify those with LDL-C >= 99th percentile for their age: first, because, in this study, 17% of the cases were molecularly diagnosed with familial hypercholesterolemia, which needs further attention; second, because our data indicate that an unfavorable lifestyle is significantly associated with severe hypercholesterolemia in genetically unaffected women, which may also need further attention.

KW - DNA copy number variations

KW - hypercholesterolemia

KW - hypobetalipoproteinemias

KW - lifestyle

KW - lipids

KW - lipoproteins

KW - risk factors

KW - CORONARY-HEART-DISEASE

KW - FAMILIAL HYPERCHOLESTEROLEMIA

KW - GENERAL-POPULATION

KW - SEQUENCE VARIATION

KW - LDL-CHOLESTEROL

KW - UNITED-STATES

KW - RISK

KW - MUTATIONS

KW - PARTICIPANTS

KW - ASSOCIATION

U2 - 10.1161/CIRCULATIONAHA.117.032479

DO - 10.1161/CIRCULATIONAHA.117.032479

M3 - Article

VL - 137

SP - 820

EP - 831

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 8

ER -

ID: 56235557