Publication

Genetic study links components of the autonomous nervous system to heart-rate profile during exercise

Verweij, N., van de Vegte, Y. J. & van der Harst, P., 1-Mar-2018, In : Nature Communications. 9, 1, 9 p., 898.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Verweij, N., van de Vegte, Y. J., & van der Harst, P. (2018). Genetic study links components of the autonomous nervous system to heart-rate profile during exercise. Nature Communications, 9(1), [898]. https://doi.org/10.1038/s41467-018-03395-6

Author

Verweij, Niek ; van de Vegte, Yordi J ; van der Harst, Pim. / Genetic study links components of the autonomous nervous system to heart-rate profile during exercise. In: Nature Communications. 2018 ; Vol. 9, No. 1.

Harvard

Verweij, N, van de Vegte, YJ & van der Harst, P 2018, 'Genetic study links components of the autonomous nervous system to heart-rate profile during exercise', Nature Communications, vol. 9, no. 1, 898. https://doi.org/10.1038/s41467-018-03395-6

Standard

Genetic study links components of the autonomous nervous system to heart-rate profile during exercise. / Verweij, Niek; van de Vegte, Yordi J; van der Harst, Pim.

In: Nature Communications, Vol. 9, No. 1, 898, 01.03.2018.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Verweij N, van de Vegte YJ, van der Harst P. Genetic study links components of the autonomous nervous system to heart-rate profile during exercise. Nature Communications. 2018 Mar 1;9(1). 898. https://doi.org/10.1038/s41467-018-03395-6


BibTeX

@article{1119439ade6e48ccaac2bb15b8f9e357,
title = "Genetic study links components of the autonomous nervous system to heart-rate profile during exercise",
abstract = "Heart rate (HR) responds to exercise by increasing during exercise and recovering after exercise. As such, HR is an important predictor of mortality that researchers believe is modulated by the autonomic nervous system. However, the mechanistic basis underlying inter-individual differences has yet to be explained. Here, we perform a large-scale genome-wide analysis of HR increase and HR recovery in 58,818 UK Biobank individuals. Twenty-five independent SNPs in 23 loci are identified to be associated (p <8.3 x 10(-9)) with HR increase or HR recovery. A total of 36 candidate causal genes are prioritized that are enriched for pathways related to neuron biology. No evidence is found of a causal relationship with mortality or cardiovascular diseases. However, a nominal association with parental lifespan requires further study. In conclusion, the findings provide new biological and clinical insight into the mechanistic underpinnings of HR response to exercise. The results also underscore the role of the autonomous nervous system in HR recovery.",
keywords = "GENOME-WIDE ASSOCIATION, RATE RECOVERY, CHRONOTROPIC INCOMPETENCE, ATRIAL-FIBRILLATION, RATE-VARIABILITY, LOCI, IDENTIFICATION, EXPRESSION, FAILURE, MORTALITY",
author = "Niek Verweij and {van de Vegte}, {Yordi J} and {van der Harst}, Pim",
year = "2018",
month = "3",
day = "1",
doi = "10.1038/s41467-018-03395-6",
language = "English",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Genetic study links components of the autonomous nervous system to heart-rate profile during exercise

AU - Verweij, Niek

AU - van de Vegte, Yordi J

AU - van der Harst, Pim

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Heart rate (HR) responds to exercise by increasing during exercise and recovering after exercise. As such, HR is an important predictor of mortality that researchers believe is modulated by the autonomic nervous system. However, the mechanistic basis underlying inter-individual differences has yet to be explained. Here, we perform a large-scale genome-wide analysis of HR increase and HR recovery in 58,818 UK Biobank individuals. Twenty-five independent SNPs in 23 loci are identified to be associated (p <8.3 x 10(-9)) with HR increase or HR recovery. A total of 36 candidate causal genes are prioritized that are enriched for pathways related to neuron biology. No evidence is found of a causal relationship with mortality or cardiovascular diseases. However, a nominal association with parental lifespan requires further study. In conclusion, the findings provide new biological and clinical insight into the mechanistic underpinnings of HR response to exercise. The results also underscore the role of the autonomous nervous system in HR recovery.

AB - Heart rate (HR) responds to exercise by increasing during exercise and recovering after exercise. As such, HR is an important predictor of mortality that researchers believe is modulated by the autonomic nervous system. However, the mechanistic basis underlying inter-individual differences has yet to be explained. Here, we perform a large-scale genome-wide analysis of HR increase and HR recovery in 58,818 UK Biobank individuals. Twenty-five independent SNPs in 23 loci are identified to be associated (p <8.3 x 10(-9)) with HR increase or HR recovery. A total of 36 candidate causal genes are prioritized that are enriched for pathways related to neuron biology. No evidence is found of a causal relationship with mortality or cardiovascular diseases. However, a nominal association with parental lifespan requires further study. In conclusion, the findings provide new biological and clinical insight into the mechanistic underpinnings of HR response to exercise. The results also underscore the role of the autonomous nervous system in HR recovery.

KW - GENOME-WIDE ASSOCIATION

KW - RATE RECOVERY

KW - CHRONOTROPIC INCOMPETENCE

KW - ATRIAL-FIBRILLATION

KW - RATE-VARIABILITY

KW - LOCI

KW - IDENTIFICATION

KW - EXPRESSION

KW - FAILURE

KW - MORTALITY

U2 - 10.1038/s41467-018-03395-6

DO - 10.1038/s41467-018-03395-6

M3 - Article

C2 - 29497042

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 898

ER -

ID: 55271010