Genetic screens in Caenorhabditis elegans models for neurodegenerative diseasesAlvarenga Fernandes Sin, O., Michels, H. & Nollen, E. A. A., Oct-2014, In : Biochimica et biophysica acta-Molecular basis of disease. 1842, 10, p. 1951-1959 9 p.
Research output: Contribution to journal › Review article › Academic › peer-review
Caenorhabditis elegans comprises unique features that make it an attractive model organism in diverse fields of biology. Genetic screens are powerful to identify genes and C. elegans can be customized to forward or reverse genetic screens and to establish gene function. These genetic screens can be applied to "humanized" models of C. elegans for neurodegenerative diseases, enabling for example the identification of genes involved in protein aggregation, one of the hallmarks of these diseases. In this review, we will describe the genetic screens employed in C. elegans and how these can be used to understand molecular processes involved in neurodegenerative and other human diseases. This article is part of a Special Issue entitled: From Genome to Function. (C) 2014 Elsevier B.V. All rights reserved.
|Number of pages||9|
|Journal||Biochimica et biophysica acta-Molecular basis of disease|
|Publication status||Published - Oct-2014|
- Caenorhabditis elegans, Nematode, Genetic screen, RNAi, EMS, Neurodegenerative disease, Modifier gene, SYSTEMATIC RNAI SCREEN, BETA-AMYLOID PEPTIDE, PARKINSONS-DISEASE, ALPHA-SYNUCLEIN, ALZHEIMERS-DISEASE, C-ELEGANS, BODY FORMATION, CELL-DEATH, LIFE-SPAN, PROTEIN