Publication

Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases

Alvarenga Fernandes Sin, O., Michels, H. & Nollen, E. A. A., Oct-2014, In : Biochimica et biophysica acta-Molecular basis of disease. 1842, 10, p. 1951-1959 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Caenorhabditis elegans comprises unique features that make it an attractive model organism in diverse fields of biology. Genetic screens are powerful to identify genes and C. elegans can be customized to forward or reverse genetic screens and to establish gene function. These genetic screens can be applied to "humanized" models of C. elegans for neurodegenerative diseases, enabling for example the identification of genes involved in protein aggregation, one of the hallmarks of these diseases. In this review, we will describe the genetic screens employed in C. elegans and how these can be used to understand molecular processes involved in neurodegenerative and other human diseases. This article is part of a Special Issue entitled: From Genome to Function. (C) 2014 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)1951-1959
Number of pages9
JournalBiochimica et biophysica acta-Molecular basis of disease
Volume1842
Issue number10
Publication statusPublished - Oct-2014

    Keywords

  • Caenorhabditis elegans, Nematode, Genetic screen, RNAi, EMS, Neurodegenerative disease, Modifier gene, SYSTEMATIC RNAI SCREEN, BETA-AMYLOID PEPTIDE, PARKINSONS-DISEASE, ALPHA-SYNUCLEIN, ALZHEIMERS-DISEASE, C-ELEGANS, BODY FORMATION, CELL-DEATH, LIFE-SPAN, PROTEIN

ID: 16265267