Genetic meta-analysis of obsessive-compulsive disorder and self-report compulsive symptoms

Smit, D. J. A., Cath, D., Zilhao, N. R., Ip, H. F., Denys, D., den Braber, A., de Geus, E. J. C., Verweij, K. J. H., Hottenga, J-J. & Boomsma, D. I., Jun-2020, In : American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 183, 4, p. 208-216 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Dirk J. A. Smit
  • Danielle Cath
  • Nuno R. Zilhao
  • Hill F. Ip
  • Damiaan Denys
  • Anouk den Braber
  • Eco J. C. de Geus
  • Karin J. H. Verweij
  • Jouke-Jan Hottenga
  • Dorret I. Boomsma

We investigated whether obsessive-compulsive (OC) symptoms from a population-based sample could be analyzed to detect genetic variants influencing obsessive-compulsive disorder (OCD). We performed a genome-wide association studies (GWAS) on the obsession (rumination and impulsions) and compulsion (checking, washing, and ordering/precision) subscales of an abbreviated version of the Padua Inventory (N = 8,267 with genome-wide genotyping and phenotyping). The compulsion subscale showed a substantial and significant positive genetic correlation with an OCD case-control GWAS (r( G) = 0.61, p = .017) previously published by the Psychiatric Genomics Consortium (PGC-OCD). The obsession subscale and the total Padua score showed no significant genetic correlations (r( G) = -0.02 and r( G) = 0.42, respectively). A meta-analysis of the compulsive symptoms GWAS with the PGC-OCD revealed no genome-wide significant Single-Nucleotide Polymorphisms (SNPs combined N = 17,992, indicating that the power is still low for individual SNP effects). A gene-based association analysis, however, yielded two novel genes (WDR7 and ADCK1). The top 250 genes in the gene-based test also showed a significant increase in enrichment for psychiatric and brain-expressed genes. S-Predixcan testing showed that for genes expressed in hippocampus, amygdala, and caudate nucleus significance increased in the meta-analysis with compulsive symptoms compared to the original PGC-OCD GWAS. Thus, the inclusion of dimensional symptom data in genome-wide association on clinical case-control GWAS of OCD may be useful to find genes for OCD if the data are based on quantitative indices of compulsive behavior. SNP-level power increases were limited, but aggregate, gene-level analyses showed increased enrichment for brain-expressed genes related to psychiatric disorders, and increased association with gene expression in brain tissues with known emotional, reward processing, memory, and fear-formation functions.

Original languageEnglish
Pages (from-to)208-216
Number of pages9
JournalAmerican Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Issue number4
Publication statusPublished - Jun-2020


  • gene expression, genome-wide association study (GWAS), obsessive-compulsive symptoms, OCD, Padua Inventory-revised, GENOME-WIDE ASSOCIATION, NUCLEUS-ACCUMBENS, TWIN

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