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Genetic manipulation of cyclic nucleotide signaling during hippocampal neuroplasticity and memory formation

Kelly, M. P., Heckman, P. R. A. & Havekes, R., Jul-2020, In : Progress in Neurobiology. 190, 21 p., 101799.

Research output: Contribution to journalReview articleAcademicpeer-review

Decades of research have underscored the importance of cyclic nucleotide signaling in memory formation and synaptic plasticity. In recent years, several new genetic techniques have expanded the neuroscience toolbox, allowing researchers to measure and modulate cyclic nucleotide gradients with high spatiotemporal resolution. Here, we will provide an overview of studies using genetic approaches to interrogate the role cyclic nucleotide signaling plays in hippocampus-dependent memory processes and synaptic plasticity. Particular attention is given to genetic techniques that measure real-time changes in cyclic nucleotide levels as well as newly-developed genetic strategies to transiently manipulate cyclic nucleotide signaling in a subcellular compartment-specific manner with high temporal resolution.

Original languageEnglish
Article number101799
Number of pages21
JournalProgress in Neurobiology
Volume190
Publication statusPublished - Jul-2020

    Keywords

  • Cyclic nucleotides, Genetic models, Memory, Neuroplasticity, Hippocampus, Phosphodiesterases, LONG-TERM POTENTIATION, PROTEIN-KINASE-A, RESONANCE ENERGY-TRANSFER, TYPE-1 ADENYLYL-CYCLASE, DEPENDENT SYNAPTIC PLASTICITY, PHOSPHODIESTERASE 11A PDE11A, IDENTIFIES PDE4D MUTATIONS, NITRIC-OXIDE, MICE DEFICIENT, VENTRAL HIPPOCAMPUS

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