Genetic loci of Staphylococcus aureus associated with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitidesGlasner, C., de Goffau, M. C., van Timmeren, M. M., Schulze, M. L., Jansen, B., Tavakol, M., van Wamel, W. J. B., Stegeman, C. A., Kallenberg, C. G. M., Arends, J. P., Rossen, J. W., Heeringa, P. & van Dijl, J. M. 22-Sep-2017 In : Scientific Reports. 7, 1, 9 p., 12211
Research output: Scientific - peer-review › Article
The proteinase 3 (PR3)-positive anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) granulomatosis with polyangiitis (GPA) has been associated with chronic nasal S. aureus carriage, which is a risk factor for disease relapse. The present study was aimed at comparing the genetic make-up of S. aureus isolates from PR3-ANCA-positive GPA patients with that of isolates from patients suffering from myeloperoxidase (MPO)-ANCA-positive AAV, and isolates from healthy controls. Based on a DNA microarray-based approach, we show that not only PR3-ANCA-positive GPA patients, but also MPO-ANCA-positive AAV patients mainly carried S. aureus types that are prevalent in the general population. Nonetheless, our data suggests that MPO-ANCA-associated S. aureus isolates may be distinct from healthy control-and PR3-ANCA-associated isolates. Furthermore, several genetic loci of S. aureus are associated with either PR3-ANCA-or MPO-ANCA-positive AAV, indicating a possible role for pore-forming toxins, such as leukocidins, in PR3-ANCA-positive GPA. Contrary to previous studies, no association between AAV and superantigens was detected. Our findings also show that a lowered humoral immune response to S. aureus is common for PR3-ANCA- and MPO-ANCA-positive AAV. Altogether, our observations imply that the presence or absence of particular virulence genes of S. aureus isolates from AAV patients contributes to disease progression and/or relapse.
|Number of pages||9|
|State||Published - 22-Sep-2017|
- ANCA-ASSOCIATED VASCULITIDES, WEGENERS-GRANULOMATOSIS, POLYANGIITIS PATIENTS, PATHOGENESIS, DISEASE, CARRIAGE, STRAINS, RELAPSE