Publication

Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes

Mazagova, M., Buikema, H., van Buiten, A., Duin, M., Goris, M., Sandovici, M., Henning, R. H. & Deelman, L. E., Nov-2013, In : American journal of physiology-Renal physiology. 305, 9, p. F1249-F1264 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Mazagova, M., Buikema, H., van Buiten, A., Duin, M., Goris, M., Sandovici, M., ... Deelman, L. E. (2013). Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes. American journal of physiology-Renal physiology, 305(9), F1249-F1264. https://doi.org/10.1152/ajprenal.00387.2013

Author

Mazagova, Magdalena ; Buikema, Hendrik ; van Buiten, Azuwerus ; Duin, Marry ; Goris, Maaike ; Sandovici, Maria ; Henning, Robert H. ; Deelman, Leo E. / Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes. In: American journal of physiology-Renal physiology. 2013 ; Vol. 305, No. 9. pp. F1249-F1264.

Harvard

Mazagova, M, Buikema, H, van Buiten, A, Duin, M, Goris, M, Sandovici, M, Henning, RH & Deelman, LE 2013, 'Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes', American journal of physiology-Renal physiology, vol. 305, no. 9, pp. F1249-F1264. https://doi.org/10.1152/ajprenal.00387.2013

Standard

Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes. / Mazagova, Magdalena; Buikema, Hendrik; van Buiten, Azuwerus; Duin, Marry; Goris, Maaike; Sandovici, Maria; Henning, Robert H.; Deelman, Leo E.

In: American journal of physiology-Renal physiology, Vol. 305, No. 9, 11.2013, p. F1249-F1264.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Mazagova M, Buikema H, van Buiten A, Duin M, Goris M, Sandovici M et al. Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes. American journal of physiology-Renal physiology. 2013 Nov;305(9):F1249-F1264. https://doi.org/10.1152/ajprenal.00387.2013


BibTeX

@article{733ea37476dd4755b086e7bf3584ece2,
title = "Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes",
abstract = "Growth differentiation factor 15 (GDF15) is emerging as valuable biomarker in cardiovascular disease and diabetic kidney disease. Also, GDF15 represents an early response gene induced after tissue injury and studies performed in GDF15 knockout (KO) mice suggest that GDF15 plays a protective role after injury. In the current study, we investigated the role of GDF15 in the development of diabetic kidney damage in type 1 and type 2 models of diabetes. Renal damage was assessed in GDF15 KO mice and wild-type (WT) mice in streptozotocin type 1 and db/db type 2 diabetic models. Genetic deletion of GDF15 augmented tubular and interstitial damage in both models of diabetes, despite similar diabetic states in KO and WT mice. Increased tubular damage in KO animals was associated with increased glucosuria and polyuria in both type 1 and type 2 models of diabetes. In both models of diabetes, KO mice showed increased interstitial damage as indicated by increased alpha-smooth muscle actin staining and collagen type 1 expression. In contrast, glomerular damage was similarly elevated in diabetic KO and WT mice. In type 1 diabetes, GDF15 KO mice demonstrated increased expression of inflammatory markers. In type 2 diabetes, elevated levels of plasma creatinine indicated impaired kidney function in KO mice. GDF15 protects the renal interstitium and tubular compartment in experimental type 1 and 2 diabetes without affecting glomerular damage.",
keywords = "diabetes, GDF15, TGF-beta, MACROPHAGE INHIBITORY CYTOKINE-1, MYOCARDIAL-INFARCTION, INDEPENDENT PREDICTOR, KIDNEY, MICE, PROTEIN, INJURY, EXPRESSION, INDIVIDUALS, ACTIVATION",
author = "Magdalena Mazagova and Hendrik Buikema and {van Buiten}, Azuwerus and Marry Duin and Maaike Goris and Maria Sandovici and Henning, {Robert H.} and Deelman, {Leo E.}",
year = "2013",
month = "11",
doi = "10.1152/ajprenal.00387.2013",
language = "English",
volume = "305",
pages = "F1249--F1264",
journal = "American journal of physiology-Renal physiology",
issn = "1931-857X",
publisher = "AMER PHYSIOLOGICAL SOC",
number = "9",

}

RIS

TY - JOUR

T1 - Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes

AU - Mazagova, Magdalena

AU - Buikema, Hendrik

AU - van Buiten, Azuwerus

AU - Duin, Marry

AU - Goris, Maaike

AU - Sandovici, Maria

AU - Henning, Robert H.

AU - Deelman, Leo E.

PY - 2013/11

Y1 - 2013/11

N2 - Growth differentiation factor 15 (GDF15) is emerging as valuable biomarker in cardiovascular disease and diabetic kidney disease. Also, GDF15 represents an early response gene induced after tissue injury and studies performed in GDF15 knockout (KO) mice suggest that GDF15 plays a protective role after injury. In the current study, we investigated the role of GDF15 in the development of diabetic kidney damage in type 1 and type 2 models of diabetes. Renal damage was assessed in GDF15 KO mice and wild-type (WT) mice in streptozotocin type 1 and db/db type 2 diabetic models. Genetic deletion of GDF15 augmented tubular and interstitial damage in both models of diabetes, despite similar diabetic states in KO and WT mice. Increased tubular damage in KO animals was associated with increased glucosuria and polyuria in both type 1 and type 2 models of diabetes. In both models of diabetes, KO mice showed increased interstitial damage as indicated by increased alpha-smooth muscle actin staining and collagen type 1 expression. In contrast, glomerular damage was similarly elevated in diabetic KO and WT mice. In type 1 diabetes, GDF15 KO mice demonstrated increased expression of inflammatory markers. In type 2 diabetes, elevated levels of plasma creatinine indicated impaired kidney function in KO mice. GDF15 protects the renal interstitium and tubular compartment in experimental type 1 and 2 diabetes without affecting glomerular damage.

AB - Growth differentiation factor 15 (GDF15) is emerging as valuable biomarker in cardiovascular disease and diabetic kidney disease. Also, GDF15 represents an early response gene induced after tissue injury and studies performed in GDF15 knockout (KO) mice suggest that GDF15 plays a protective role after injury. In the current study, we investigated the role of GDF15 in the development of diabetic kidney damage in type 1 and type 2 models of diabetes. Renal damage was assessed in GDF15 KO mice and wild-type (WT) mice in streptozotocin type 1 and db/db type 2 diabetic models. Genetic deletion of GDF15 augmented tubular and interstitial damage in both models of diabetes, despite similar diabetic states in KO and WT mice. Increased tubular damage in KO animals was associated with increased glucosuria and polyuria in both type 1 and type 2 models of diabetes. In both models of diabetes, KO mice showed increased interstitial damage as indicated by increased alpha-smooth muscle actin staining and collagen type 1 expression. In contrast, glomerular damage was similarly elevated in diabetic KO and WT mice. In type 1 diabetes, GDF15 KO mice demonstrated increased expression of inflammatory markers. In type 2 diabetes, elevated levels of plasma creatinine indicated impaired kidney function in KO mice. GDF15 protects the renal interstitium and tubular compartment in experimental type 1 and 2 diabetes without affecting glomerular damage.

KW - diabetes

KW - GDF15

KW - TGF-beta

KW - MACROPHAGE INHIBITORY CYTOKINE-1

KW - MYOCARDIAL-INFARCTION

KW - INDEPENDENT PREDICTOR

KW - KIDNEY

KW - MICE

KW - PROTEIN

KW - INJURY

KW - EXPRESSION

KW - INDIVIDUALS

KW - ACTIVATION

U2 - 10.1152/ajprenal.00387.2013

DO - 10.1152/ajprenal.00387.2013

M3 - Article

VL - 305

SP - F1249-F1264

JO - American journal of physiology-Renal physiology

JF - American journal of physiology-Renal physiology

SN - 1931-857X

IS - 9

ER -

ID: 5986630