Publication

Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility

de Jong, MM., Nolte, IM., Meerman, GJT., van der Graaf, WTA., Oosterwijk, JC., Kleibeuker, JH., Schaapveld, M. & de Vries, EGE., Apr-2002, In : JOURNAL OF MEDICAL GENETICS. 39, 4, p. 225-242 18 p.

Research output: Contribution to journalReview articleAcademicpeer-review

This review focuses on genes other than the high penetrance genes BRCA1 and BRCA2 that are involved in breast cancer susceptibility. The goal of this review is the discovery of polymorphisms that are either associated with breast cancer or that are in strong linkage disequilibrium with breast cancer causing variants. An association with breast cancer at a 5% significance level was found for 13 polymorphisms in 10 genes described in more than one breast cancer study. Our data will help focus on the further analysis of genetic polymorphisms in populations of appropriate size, and especially on the combinations of such polymorphisms. This will facilitate determination of population attributable risks, understanding of gene-gene interactions, and improving estimates of genetic cancer risks.

Original languageEnglish
Pages (from-to)225-242
Number of pages18
JournalJOURNAL OF MEDICAL GENETICS
Volume39
Issue number4
Publication statusPublished - Apr-2002

    Keywords

  • CATECHOL-O-METHYLTRANSFERASE, PROGESTERONE-RECEPTOR GENE, TUMOR-SUPPRESSOR GENE, S-TRANSFERASE M1, FRAGMENT-LENGTH-POLYMORPHISM, PEUTZ-JEGHERS-SYNDROME, ATAXIA-TELANGIECTASIA HETEROZYGOTES, TETRANUCLEOTIDE REPEAT POLYMORPHISM, MAJOR HISTOCOMPATIBILITY COMPLEX, CYTOCHROME P4501A1 POLYMORPHISM

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