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Gender Differences in Renin Angiotensin Aldosterone System Affect Extra Cellular Volume in Healthy Subjects

Toering, T. J., Gant, C. M., Visser, F. W., van der Graaf, A. M., Laverman, G. D., Danser, A. H. J., Faas, M. M., Navis, G. & Lely, A. T., May-2018, In : American journal of physiology-Renal physiology. 314, 5, p. F873-F878 6 p.

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  • Sex differences in renin-angiotensin-aldosterone system

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DOI

OBJECTIVE Several studies reported gender differences in aldosterone. It is unknown whether these differences are associated with differences in volume regulation. Therefore, we studied both aldosterone and extracellular volume in men and women on different sodium intakes. METHODS In healthy normotensive men (n=18) and premenopausal women (n=18) we investigated plasma aldosterone, blood pressure, and extracellular volume (125I-iothalamate), during both a low (target intake 50 mmol Na+/day) and high sodium intake (target intake 200 mmol Na+/day) in a cross-over set-up. Furthermore, we studied the adrenal response to angiotensin II infusion (0.3, 1.0 and 3.0 ng/kg/min for 1 h) on both sodium intakes. RESULTS Men had a significantly higher plasma aldosterone, extracellular volume and systolic blood pressure than women during a high sodium intake (p<0.05). During a low sodium intake, extracellular volume and blood pressure were higher in men as well (p<0.05), whereas the difference in plasma aldosterone was no longer significant (P=0.252). The adrenal response to exogenous angiotensin II was significantly lower in men than in women on both sodium intakes. CONCLUSIONS Constitutive gender differences in the regulation of aldosterone, characterized by a higher aldosterone and a lower adrenal response to exogenous angiotensin II infusion in men, are associated with a higher extracellular volume and blood pressure in men. These findings suggest that gender differences in the regulation of aldosterone contribute to differences in volume regulation between men and women.

Original languageEnglish
Pages (from-to)F873-F878
Number of pages6
JournalAmerican journal of physiology-Renal physiology
Volume314
Issue number5
Early online date4-Dec-2017
Publication statusPublished - May-2018

    Keywords

  • Journal Article, SODIUM, DIMORPHISM, CONVERTING-ENZYME-INHIBITION, AMBULATORY BLOOD-PRESSURE, ESSENTIAL-HYPERTENSION, MENSTRUAL-CYCLE, RENAL-RESPONSE, GENDER-DIFFERENCES, FLUID VOLUME, AGE

ID: 42761251