Publication

Gasotransmitters in health and disease: a mitochondria-centered view

Hendriks, K. D., Maassen, H., van Dijk, P. R., Henning, R. H., van Goor, H. & Hillebrands, J-L., Apr-2019, In : Current Opinion in Pharmacology. 45, p. 87-93 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

DOI

Gasotransmitters fulfill important roles in cellular homeostasis having been linked to various pathologies, including inflammation and cardiovascular diseases. In addition to the known pathways mediating the actions of gasotransmitters, their effects in regulating mitochondrial function are emerging. Given that mitochondria are key organelles in energy production, formation of reactive oxygen species and apoptosis, they are important mediators in preserving health and disease. Preserving or restoring mitochondrial function by gasotransmitters may be beneficial, and mitigate pathogenetic processes. In this review we discuss the actions of gasotransmitters with focus on their role in mitochondrial function and their therapeutic potential.

Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume45
Publication statusPublished - Apr-2019

    Keywords

  • HYDROGEN-SULFIDE, NITRIC-OXIDE, ISCHEMIA-REPERFUSION, CARBON-MONOXIDE, CELL APOPTOSIS, INJURY, PROTECTS, MECHANISMS, INFLAMMATION, DYSFUNCTION

Download statistics

No data available

ID: 91359468