Publication

Gap junctional channels are parts of multiprotein complexes

Herve, J-C., Derangeon, M., Sarrouilhe, D., Giepmans, B. N. G. & Bourmeyster, N., Aug-2012, In : Biochimica et Biophysica Acta-Biomembranes. 1818, 8, p. 1844-1865 22 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Gap junctional channels are a class of membrane channels composed of transmembrane channel-forming integral membrane proteins termed connexins, innexins or pannexins that mediate direct cell-to-cell or cell-to extracellular medium communication in almost all animal tissues. The activity of these channels is tightly regulated, particularly by intramolecular modifications as phosphorylations of proteins and via the formation of multiprotein complexes where pore-forming subunits bind to auxiliary channel subunits and associate with scaffolding proteins that play essential roles in channel localization and activity. Scaffolding proteins link signaling enzymes, substrates, and potential effectors (such as channels) into multiprotein signaling complexes that may be anchored to the cytoskeleton. Protein-protein interactions play essential roles in channel localization and activity and, besides their cell-to-cell channel-forming functions, gap junctional proteins now appear involved in different cellular functions (e.g. transcriptional and cytoskeletal regulations). The present review summarizes the recent progress regarding the proteins capable of interacting with junctional proteins and highlights the function of these protein-protein interactions in cell physiology and aberrant function in diseases. This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and functions. (C) 2011 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)1844-1865
Number of pages22
JournalBiochimica et Biophysica Acta-Biomembranes
Volume1818
Issue number8
Publication statusPublished - Aug-2012

    Keywords

  • Connexin, Pannexin, Innexin, Zonula Occludens, Protein-protein, PROTEIN-KINASE-C, ZONULA OCCLUDENS PROTEIN-1, RIGHT-VENTRICULAR DYSPLASIA/CARDIOMYOPATHY, CARBOXYL-TERMINAL DOMAIN, CENTRAL-NERVOUS-SYSTEM, ACID-BINDING PROTEIN, BLOOD-TESTIS BARRIER, SMOOTH-MUSCLE-CELLS, 2ND PDZ DOMAIN, F-BOX PROTEIN

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