Publication

Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal

Jia, J., Claude-Taupin, A., Gu, Y., Choi, S. W., Peters, R., Bissa, B., Mudd, M. H., Allers, L., Pallikkuth, S., Lidke, K. A., Salemi, M., Phinney, B., Mari, M., Reggiori, F. & Deretic, V., 6-Jan-2020, In : Developmental Cell. 52, 1, p. 69-+ 27 p.

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  • Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal _ Elsevier Enhanced Reader

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DOI

  • Jingyue Jia
  • Aurore Claude-Taupin
  • Yuexi Gu
  • Seong Won Choi
  • Ryan Peters
  • Bhawana Bissa
  • Michal H. Mudd
  • Lee Allers
  • Sandeep Pallikkuth
  • Keith A. Lidke
  • Michelle Salemi
  • Brett Phinney
  • Muriel Mari
  • Fulvio Reggiori
  • Vojo Deretic

Jia et al. show that Galectin-3 recruits ESCRT components to damaged lysosomes for repair and restoration of their function. During sustained lysosomal injury, galectins induce autophagy and lysosomal biogenesis for a staged repair, removal, and replacement program. This response is deployed during damage with neurotoxic tau or Mycobacterium tuberculosis infection.

Original languageEnglish
Pages (from-to)69-+
Number of pages27
JournalDevelopmental Cell
Volume52
Issue number1
Early online date29-Nov-2019
Publication statusPublished - 6-Jan-2020

    Keywords

  • PROTEIN CONJUGATION SYSTEM, ULK1 COMPLEX, AUTOPHAGOSOME FORMATION, REGULATE AUTOPHAGY, DAMAGED LYSOSOMES, ESCRT MACHINERY, MEMBRANE, MTOR, RECRUITMENT, MECHANISM

ID: 108434097