Gadoxetic acid disodium-enhanced MR imaging of cholangiolocellular carcinoma of the liver: imaging characteristics and histopathological correlationsHaradome, H., Unno, T., Morisaka, H., Toda, Y., Kwee, T. C., Kondo, H., Sano, K., Ichikawa, T., Kondo, F., Sugitani, M. & Takayama, T., Nov-2017, In : European Radiology. 27, 11, p. 4461-4471 11 p.
Research output: Contribution to journal › Article › Academic › peer-review
Objectives To review the gadoxetic acid disodium (EOB)-enhanced magnetic resonance (MR) imaging features of cholangiolocellular carcinoma (CoCC) of the liver and compare them with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).
Methods EOB-enhanced MR images of 19 patients with CoCC, 23 with ICC, and 51 with HCC were retrospectively evaluated qualitatively and quantitatively. Univariate and multivariate analyses were performed to determine the characteristic MR features of CoCC with histopathological-imaging correlation.
Results Multivariate logistic regression analysis showed that dot-/band-shaped internal enhancement during the arterial and portal phases (P <0.001), and larger arterial ring enhancement ratio (CoCC, 0.13 +/- 0.04; ICC, 0.074 +/- 0.04; P = 0.013) were significantly independently associated with CoCC in contrast to ICC, whereas several MR features including progressive enhancement during the portal and late phases (P <0.001), target appearance in the hepatocyte phase (P = 0.004), and vessel penetration (P = 0.013) were significantly more frequently associated with CoCC than HCC. The dot-/band-like internal enhancement (78.9% of CoCCs) histopathologically corresponded to the tumour cell nest with vascular proliferations and retained Glisson's sheath structure.
Conclusions EOB-enhanced MR features of CoCC largely differ from those of HCC but are similar to those of ICC. However, the finding of thicker arterial ring enhancement with dot-/band-like internal enhancement could help differentiate CoCC from ICC.
|Number of pages||11|
|Publication status||Published - Nov-2017|
- Liver, Gadoxetic acid disodium-enhanced magnetic resonance imaging, Cholangiolocellular carcinoma, Intrahepatic cholangiocarcinoma Hepatocellular carcinoma, GD-EOB-DTPA, FOCAL NODULAR HYPERPLASIA, HEPATOBILIARY PHASE, HEPATOCELLULAR-CARCINOMA, INTRAHEPATIC CHOLANGIOCARCINOMA, TARGET SIGN, DIAGNOSIS, ADENOMA, IMAGES, CT