Publication

Functional neuroimaging of associative learning and generalization in specific phobia

Lange, I., Goossens, L., Bakker, J., Michielse, S., Marcelis, M., Wichers, M., van Os, J., van Amelsvoort, T. & Schruers, K., 8-Mar-2019, In : Progress in Neuro-Psychopharmacology & Biological Psychiatry. 89, p. 275-285 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Lange, I., Goossens, L., Bakker, J., Michielse, S., Marcelis, M., Wichers, M., ... Schruers, K. (2019). Functional neuroimaging of associative learning and generalization in specific phobia. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 89, 275-285. https://doi.org/10.1016/j.pnpbp.2018.09.008

Author

Lange, Iris ; Goossens, Liesbet ; Bakker, Jindra ; Michielse, Stijn ; Marcelis, Machteld ; Wichers, Marieke ; van Os, Jim ; van Amelsvoort, Therese ; Schruers, Koen. / Functional neuroimaging of associative learning and generalization in specific phobia. In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2019 ; Vol. 89. pp. 275-285.

Harvard

Lange, I, Goossens, L, Bakker, J, Michielse, S, Marcelis, M, Wichers, M, van Os, J, van Amelsvoort, T & Schruers, K 2019, 'Functional neuroimaging of associative learning and generalization in specific phobia', Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 89, pp. 275-285. https://doi.org/10.1016/j.pnpbp.2018.09.008

Standard

Functional neuroimaging of associative learning and generalization in specific phobia. / Lange, Iris; Goossens, Liesbet; Bakker, Jindra; Michielse, Stijn; Marcelis, Machteld; Wichers, Marieke; van Os, Jim; van Amelsvoort, Therese; Schruers, Koen.

In: Progress in Neuro-Psychopharmacology & Biological Psychiatry, Vol. 89, 08.03.2019, p. 275-285.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Lange I, Goossens L, Bakker J, Michielse S, Marcelis M, Wichers M et al. Functional neuroimaging of associative learning and generalization in specific phobia. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2019 Mar 8;89:275-285. https://doi.org/10.1016/j.pnpbp.2018.09.008


BibTeX

@article{6a21066f6f4044f9b6474250a741b5be,
title = "Functional neuroimaging of associative learning and generalization in specific phobia",
abstract = "Background: Theoretical models have implicated classical fear conditioning, fear generalization, and extinction learning in the development of anxiety disorders. To date, it is largely unknown to what extent these mechanisms and the underlying neurobiology may be altered in specific phobia, a disorder characterized by focal fears. The current study systematically examined fear conditioning, fear generalization, extinction learning, and extinction recall in a sample of individuals with a specific phobia.Methods: Participants with a specific phobia (SP) of spiders (n = 46) and healthy controls (HC) (n = 48) underwent a 3-day fMRI cue-conditioning protocol, including a fear acquisition and a fear generalization phase (day 1), an extinction learning phase (day 2), and an extinction recall phase (day 3). Stimuli were phobia-irrelevant, as geometrical shapes served as conditioned threat (CS + ) and safety stimuli (CS-), and an electrical shock as the unconditioned stimulus (US). Self-reported fear, US expectancy, and blood-oxygen-level dependent responses were measured.Results: Behavioral results only revealed enhanced CS + /CS-differentiation in fear scores during acquisition retention in SP. Some neural differences were observed during other task phases. During early fear acquisition, SP showed enhanced differential activation in the angular gyrus and lateral occipital cortex, and during extinction recall, more precuneus deactivation was found in SP compared to HC. There were no clear indications of altered neural fear generalization or extinction learning mechanisms in the SP group.Conclusions: Results indicate that spider phobia may be characterized by enhanced differential fear retention and altered brain activation patterns during fear acquisition and extinction recall. The findings provide insight into the nature of fear learning alterations in specific phobia, and how these may differ from those found in disorders characterized by broad anxious distress.",
keywords = "Specific phobia, Fear learning, Fear generalization, Extinction learning, Extinction recall, fMRI, VENTROMEDIAL PREFRONTAL CORTEX, POSTTRAUMATIC-STRESS-DISORDER, DEFAULT MODE NETWORK, ANXIETY DISORDERS, CONDITIONED FEAR, REFLEX PHYSIOLOGY, PANIC DISORDER, TRAIT ANXIETY, EXTINCTION, ACQUISITION",
author = "Iris Lange and Liesbet Goossens and Jindra Bakker and Stijn Michielse and Machteld Marcelis and Marieke Wichers and {van Os}, Jim and {van Amelsvoort}, Therese and Koen Schruers",
year = "2019",
month = "3",
day = "8",
doi = "10.1016/j.pnpbp.2018.09.008",
language = "English",
volume = "89",
pages = "275--285",
journal = "Progress in Neuro-Psychopharmacology & Biological Psychiatry",
issn = "1878-4216",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - Functional neuroimaging of associative learning and generalization in specific phobia

AU - Lange, Iris

AU - Goossens, Liesbet

AU - Bakker, Jindra

AU - Michielse, Stijn

AU - Marcelis, Machteld

AU - Wichers, Marieke

AU - van Os, Jim

AU - van Amelsvoort, Therese

AU - Schruers, Koen

PY - 2019/3/8

Y1 - 2019/3/8

N2 - Background: Theoretical models have implicated classical fear conditioning, fear generalization, and extinction learning in the development of anxiety disorders. To date, it is largely unknown to what extent these mechanisms and the underlying neurobiology may be altered in specific phobia, a disorder characterized by focal fears. The current study systematically examined fear conditioning, fear generalization, extinction learning, and extinction recall in a sample of individuals with a specific phobia.Methods: Participants with a specific phobia (SP) of spiders (n = 46) and healthy controls (HC) (n = 48) underwent a 3-day fMRI cue-conditioning protocol, including a fear acquisition and a fear generalization phase (day 1), an extinction learning phase (day 2), and an extinction recall phase (day 3). Stimuli were phobia-irrelevant, as geometrical shapes served as conditioned threat (CS + ) and safety stimuli (CS-), and an electrical shock as the unconditioned stimulus (US). Self-reported fear, US expectancy, and blood-oxygen-level dependent responses were measured.Results: Behavioral results only revealed enhanced CS + /CS-differentiation in fear scores during acquisition retention in SP. Some neural differences were observed during other task phases. During early fear acquisition, SP showed enhanced differential activation in the angular gyrus and lateral occipital cortex, and during extinction recall, more precuneus deactivation was found in SP compared to HC. There were no clear indications of altered neural fear generalization or extinction learning mechanisms in the SP group.Conclusions: Results indicate that spider phobia may be characterized by enhanced differential fear retention and altered brain activation patterns during fear acquisition and extinction recall. The findings provide insight into the nature of fear learning alterations in specific phobia, and how these may differ from those found in disorders characterized by broad anxious distress.

AB - Background: Theoretical models have implicated classical fear conditioning, fear generalization, and extinction learning in the development of anxiety disorders. To date, it is largely unknown to what extent these mechanisms and the underlying neurobiology may be altered in specific phobia, a disorder characterized by focal fears. The current study systematically examined fear conditioning, fear generalization, extinction learning, and extinction recall in a sample of individuals with a specific phobia.Methods: Participants with a specific phobia (SP) of spiders (n = 46) and healthy controls (HC) (n = 48) underwent a 3-day fMRI cue-conditioning protocol, including a fear acquisition and a fear generalization phase (day 1), an extinction learning phase (day 2), and an extinction recall phase (day 3). Stimuli were phobia-irrelevant, as geometrical shapes served as conditioned threat (CS + ) and safety stimuli (CS-), and an electrical shock as the unconditioned stimulus (US). Self-reported fear, US expectancy, and blood-oxygen-level dependent responses were measured.Results: Behavioral results only revealed enhanced CS + /CS-differentiation in fear scores during acquisition retention in SP. Some neural differences were observed during other task phases. During early fear acquisition, SP showed enhanced differential activation in the angular gyrus and lateral occipital cortex, and during extinction recall, more precuneus deactivation was found in SP compared to HC. There were no clear indications of altered neural fear generalization or extinction learning mechanisms in the SP group.Conclusions: Results indicate that spider phobia may be characterized by enhanced differential fear retention and altered brain activation patterns during fear acquisition and extinction recall. The findings provide insight into the nature of fear learning alterations in specific phobia, and how these may differ from those found in disorders characterized by broad anxious distress.

KW - Specific phobia

KW - Fear learning

KW - Fear generalization

KW - Extinction learning

KW - Extinction recall

KW - fMRI

KW - VENTROMEDIAL PREFRONTAL CORTEX

KW - POSTTRAUMATIC-STRESS-DISORDER

KW - DEFAULT MODE NETWORK

KW - ANXIETY DISORDERS

KW - CONDITIONED FEAR

KW - REFLEX PHYSIOLOGY

KW - PANIC DISORDER

KW - TRAIT ANXIETY

KW - EXTINCTION

KW - ACQUISITION

U2 - 10.1016/j.pnpbp.2018.09.008

DO - 10.1016/j.pnpbp.2018.09.008

M3 - Article

VL - 89

SP - 275

EP - 285

JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry

SN - 1878-4216

ER -

ID: 77219412