Publication

Functional integrity and aging of the left internal thoracic artery after coronary artery bypass surgery

Amoroso, G., Tio, RA., Mariani, MA., van Boven, AJ., Jessurun, GAJ., Monnink, SHJ., Grandjean, JG., Boonstra, PW. & Crijns, HJGM., Aug-2000, In : JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY. 120, 2, p. 313-318 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • G Amoroso
  • RA Tio
  • MA Mariani
  • AJ van Boven
  • GAJ Jessurun
  • SHJ Monnink
  • JG Grandjean
  • PW Boonstra
  • HJGM Crijns

Objective: To study the endothelial function in the left internal thoracic artery after coronary artery bypass surgery and to identify predictors of early dysfunction, we performed a provocative test with acetylcholine in 23 male patients who underwent routine postoperative coronary angiography.

Methods: The change in mean diameter of the proximal thoracic artery was assessed by quantitative angiography after selective injections of acetylcholine and nitroglycerin.

Results: The thoracic artery showed a 6.8% (P

Conclusions: Endothelium-dependent vasodilative response to acetylcholine administration seems well preserved in the left internal thoracic artery after surgery. Common risk factors, except for age, do not affect the functional integrity of the arterial graft. The vasodilative properties of the graft depend on the age of the patient and do not deteriorate over time after operation.

Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalJOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
Volume120
Issue number2
Publication statusPublished - Aug-2000

    Keywords

  • ENDOTHELIUM-DEPENDENT RELAXATION, MAMMARY ARTERY, GASTROEPIPLOIC ARTERIES, GRAFTS, ACETYLCHOLINE, RESPONSES, DISEASE, FLOW

ID: 3881771