Publication

Functional impact of subthalamotomy by magnetic resonance-guided focused ultrasound in Parkinson's disease: a hybrid PET/MR study of resting-state brain metabolism

Rodriguez-Rojas, R., Pineda-Pardo, J. A., Martinez-Fernandez, R., Kogan, R. V., Sanchez-Catasus, C. A., del Alamo, M., Hernandez, F., Garcia-Canamaque, L., Leenders, K. L. & Obeso, J. A., 8-Nov-2019, In : European Journal of Nuclear Medicine and Molecular Imaging. 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Rodriguez-Rojas, R., Pineda-Pardo, J. A., Martinez-Fernandez, R., Kogan, R. V., Sanchez-Catasus, C. A., del Alamo, M., ... Obeso, J. A. (2019). Functional impact of subthalamotomy by magnetic resonance-guided focused ultrasound in Parkinson's disease: a hybrid PET/MR study of resting-state brain metabolism. European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-019-04497-z

Author

Rodriguez-Rojas, Rafael ; Pineda-Pardo, Jose A. ; Martinez-Fernandez, Raul ; Kogan, Rosalie V. ; Sanchez-Catasus, Carlos A. ; del Alamo, Marta ; Hernandez, Frida ; Garcia-Canamaque, Lina ; Leenders, Klaus L. ; Obeso, Jose A. / Functional impact of subthalamotomy by magnetic resonance-guided focused ultrasound in Parkinson's disease : a hybrid PET/MR study of resting-state brain metabolism. In: European Journal of Nuclear Medicine and Molecular Imaging. 2019.

Harvard

Rodriguez-Rojas, R, Pineda-Pardo, JA, Martinez-Fernandez, R, Kogan, RV, Sanchez-Catasus, CA, del Alamo, M, Hernandez, F, Garcia-Canamaque, L, Leenders, KL & Obeso, JA 2019, 'Functional impact of subthalamotomy by magnetic resonance-guided focused ultrasound in Parkinson's disease: a hybrid PET/MR study of resting-state brain metabolism', European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-019-04497-z

Standard

Functional impact of subthalamotomy by magnetic resonance-guided focused ultrasound in Parkinson's disease : a hybrid PET/MR study of resting-state brain metabolism. / Rodriguez-Rojas, Rafael; Pineda-Pardo, Jose A.; Martinez-Fernandez, Raul; Kogan, Rosalie V.; Sanchez-Catasus, Carlos A.; del Alamo, Marta; Hernandez, Frida; Garcia-Canamaque, Lina; Leenders, Klaus L.; Obeso, Jose A.

In: European Journal of Nuclear Medicine and Molecular Imaging, 08.11.2019.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Rodriguez-Rojas R, Pineda-Pardo JA, Martinez-Fernandez R, Kogan RV, Sanchez-Catasus CA, del Alamo M et al. Functional impact of subthalamotomy by magnetic resonance-guided focused ultrasound in Parkinson's disease: a hybrid PET/MR study of resting-state brain metabolism. European Journal of Nuclear Medicine and Molecular Imaging. 2019 Nov 8. https://doi.org/10.1007/s00259-019-04497-z


BibTeX

@article{a7d383247d6d4df98c3b4014e5de4736,
title = "Functional impact of subthalamotomy by magnetic resonance-guided focused ultrasound in Parkinson's disease: a hybrid PET/MR study of resting-state brain metabolism",
abstract = "Purpose Subthalamotomy using magnetic resonance-guided focused ultrasound (MRgFUS) has become a potential treatment option for the cardinal features of Parkinson's disease (PD). The purpose of this study was to evaluate the effects of MRgFUS-subthalamotomy on brain metabolism using different scale levels. Methods We studied resting-state glucose metabolism in eight PD patients before and after unilateral MRgFUS-subthalamotomy using hybrid [F-18]FDG-PET/MR imaging. We used statistical nonparametric mapping (SnPM) to study regional metabolic changes following this treatment and also quantified whole-brain treatment-related changes in the expression of a spatial covariance-based Parkinson's disease-related metabolic brain pattern (PDRP). Modulation of regional and network activity was correlated with clinical improvement as measured by changes in Unified Parkinson's Disease Rating Scale (MDS-UPDRS) motor scores. Results After subthalamotomy, there was a significant reduction in FDG uptake in the subthalamic region, globus pallidus internus, motor and premotor cortical regions, and cingulate gyrus in the treated hemisphere, and the contralateral cerebellum (p <0.001). Diffuse metabolic increase was found in the posterior parietal and occipital areas. Treatment also resulted in a significant decline in PDRP expression (p <0.05), which correlated with clinical improvement in UPDRS motor scores (rho = 0.760; p = 0.002). Conclusions MRgFUS-subthalamotomy induced metabolic alterations in distributed nodes of the motor, associative, and limbic circuits. Clinical improvement was associated with reduction in the PDRP expression. This treatment-induced modulation of the metabolic network is likely to mediate the clinical benefit achieved following MRgFUS-subthalamotomy.",
keywords = "Parkinson's disease, MR-guided focused ultrasound, Subthalamotomy, Positron emission tomography, Metabolic brain network, FDG-PET, BASAL GANGLIA, NETWORK, NUCLEUS, PATTERNS, MRI, HYPOMETABOLISM, STIMULATION, NEUROLOGY",
author = "Rafael Rodriguez-Rojas and Pineda-Pardo, {Jose A.} and Raul Martinez-Fernandez and Kogan, {Rosalie V.} and Sanchez-Catasus, {Carlos A.} and {del Alamo}, Marta and Frida Hernandez and Lina Garcia-Canamaque and Leenders, {Klaus L.} and Obeso, {Jose A.}",
year = "2019",
month = "11",
day = "8",
doi = "10.1007/s00259-019-04497-z",
language = "English",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
issn = "1619-7070",
publisher = "SPRINGER",

}

RIS

TY - JOUR

T1 - Functional impact of subthalamotomy by magnetic resonance-guided focused ultrasound in Parkinson's disease

T2 - a hybrid PET/MR study of resting-state brain metabolism

AU - Rodriguez-Rojas, Rafael

AU - Pineda-Pardo, Jose A.

AU - Martinez-Fernandez, Raul

AU - Kogan, Rosalie V.

AU - Sanchez-Catasus, Carlos A.

AU - del Alamo, Marta

AU - Hernandez, Frida

AU - Garcia-Canamaque, Lina

AU - Leenders, Klaus L.

AU - Obeso, Jose A.

PY - 2019/11/8

Y1 - 2019/11/8

N2 - Purpose Subthalamotomy using magnetic resonance-guided focused ultrasound (MRgFUS) has become a potential treatment option for the cardinal features of Parkinson's disease (PD). The purpose of this study was to evaluate the effects of MRgFUS-subthalamotomy on brain metabolism using different scale levels. Methods We studied resting-state glucose metabolism in eight PD patients before and after unilateral MRgFUS-subthalamotomy using hybrid [F-18]FDG-PET/MR imaging. We used statistical nonparametric mapping (SnPM) to study regional metabolic changes following this treatment and also quantified whole-brain treatment-related changes in the expression of a spatial covariance-based Parkinson's disease-related metabolic brain pattern (PDRP). Modulation of regional and network activity was correlated with clinical improvement as measured by changes in Unified Parkinson's Disease Rating Scale (MDS-UPDRS) motor scores. Results After subthalamotomy, there was a significant reduction in FDG uptake in the subthalamic region, globus pallidus internus, motor and premotor cortical regions, and cingulate gyrus in the treated hemisphere, and the contralateral cerebellum (p <0.001). Diffuse metabolic increase was found in the posterior parietal and occipital areas. Treatment also resulted in a significant decline in PDRP expression (p <0.05), which correlated with clinical improvement in UPDRS motor scores (rho = 0.760; p = 0.002). Conclusions MRgFUS-subthalamotomy induced metabolic alterations in distributed nodes of the motor, associative, and limbic circuits. Clinical improvement was associated with reduction in the PDRP expression. This treatment-induced modulation of the metabolic network is likely to mediate the clinical benefit achieved following MRgFUS-subthalamotomy.

AB - Purpose Subthalamotomy using magnetic resonance-guided focused ultrasound (MRgFUS) has become a potential treatment option for the cardinal features of Parkinson's disease (PD). The purpose of this study was to evaluate the effects of MRgFUS-subthalamotomy on brain metabolism using different scale levels. Methods We studied resting-state glucose metabolism in eight PD patients before and after unilateral MRgFUS-subthalamotomy using hybrid [F-18]FDG-PET/MR imaging. We used statistical nonparametric mapping (SnPM) to study regional metabolic changes following this treatment and also quantified whole-brain treatment-related changes in the expression of a spatial covariance-based Parkinson's disease-related metabolic brain pattern (PDRP). Modulation of regional and network activity was correlated with clinical improvement as measured by changes in Unified Parkinson's Disease Rating Scale (MDS-UPDRS) motor scores. Results After subthalamotomy, there was a significant reduction in FDG uptake in the subthalamic region, globus pallidus internus, motor and premotor cortical regions, and cingulate gyrus in the treated hemisphere, and the contralateral cerebellum (p <0.001). Diffuse metabolic increase was found in the posterior parietal and occipital areas. Treatment also resulted in a significant decline in PDRP expression (p <0.05), which correlated with clinical improvement in UPDRS motor scores (rho = 0.760; p = 0.002). Conclusions MRgFUS-subthalamotomy induced metabolic alterations in distributed nodes of the motor, associative, and limbic circuits. Clinical improvement was associated with reduction in the PDRP expression. This treatment-induced modulation of the metabolic network is likely to mediate the clinical benefit achieved following MRgFUS-subthalamotomy.

KW - Parkinson's disease

KW - MR-guided focused ultrasound

KW - Subthalamotomy

KW - Positron emission tomography

KW - Metabolic brain network

KW - FDG-PET

KW - BASAL GANGLIA

KW - NETWORK

KW - NUCLEUS

KW - PATTERNS

KW - MRI

KW - HYPOMETABOLISM

KW - STIMULATION

KW - NEUROLOGY

U2 - 10.1007/s00259-019-04497-z

DO - 10.1007/s00259-019-04497-z

M3 - Article

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

ER -

ID: 101950144