Functional evaluation of peripheral nerve regeneration in the rat: walking track analysis

Varejao, ASP., Meek, MF., Patricio, JAB. & Cabrita, AMS., 15-Jul-2001, In : Journal of Neuroscience Methods. 108, 1, p. 1-9 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

  • ASP Varejao
  • MF Meek
  • JAB Patricio
  • AMS Cabrita

The experimental model of choice for many peripheral nerve investigators is the rat. Walking track analysis is a useful tool in the evaluation of functional peripheral nerve recovery in the rat. This quantitative method of analyzing hind limbs performance by examining footprints, known as the sciatic function index (SFI), has been widely used to quantify functional recovery from sciatic nerve injury in a number of different injury models, although some limitations of the SFI has been questioned by several authors. This article is designed to offer the peripheral nerve investigator a noninvasive method to evaluate quantitatively the integrated motor recovery in experimental studies. (C) 2001 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of Neuroscience Methods
Issue number1
Publication statusPublished - 15-Jul-2001


  • peripheral nerve regeneration, rat sciatic nerve, functional nerve recovery, walking track analysis, toe spread, limitations of sciatic function index, SCIATIC FUNCTION INDEX, TIBIAL NERVE, MUSCLE-CONTRACTION, FOOTPRINT ANALYSIS, EXPERIMENTAL-MODEL, CONDUCTION TESTS, AXON MORPHOMETRY, VIDEO ANALYSIS, RECOVERY, REPAIR

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