Publication

From tissue invasion to glucose metabolism: the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities

Pensa, S., Demaria, M., Avalle, L., Barbieri, I., Camporeale, A. & Poli, V., Jun-2012, In : Hormone Molecular Biology and Clinical Investigation. 10, 1, p. 217-25 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Pensa, S., Demaria, M., Avalle, L., Barbieri, I., Camporeale, A., & Poli, V. (2012). From tissue invasion to glucose metabolism: the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities. Hormone Molecular Biology and Clinical Investigation, 10(1), 217-25. https://doi.org/10.1515/hmbci-2012-0006

Author

Pensa, Sara ; Demaria, Marco ; Avalle, Lidia ; Barbieri, Isaia ; Camporeale, Annalisa ; Poli, Valeria. / From tissue invasion to glucose metabolism : the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities. In: Hormone Molecular Biology and Clinical Investigation. 2012 ; Vol. 10, No. 1. pp. 217-25.

Harvard

Pensa, S, Demaria, M, Avalle, L, Barbieri, I, Camporeale, A & Poli, V 2012, 'From tissue invasion to glucose metabolism: the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities' Hormone Molecular Biology and Clinical Investigation, vol. 10, no. 1, pp. 217-25. https://doi.org/10.1515/hmbci-2012-0006

Standard

From tissue invasion to glucose metabolism : the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities. / Pensa, Sara; Demaria, Marco; Avalle, Lidia; Barbieri, Isaia; Camporeale, Annalisa; Poli, Valeria.

In: Hormone Molecular Biology and Clinical Investigation, Vol. 10, No. 1, 06.2012, p. 217-25.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Pensa S, Demaria M, Avalle L, Barbieri I, Camporeale A, Poli V. From tissue invasion to glucose metabolism: the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities. Hormone Molecular Biology and Clinical Investigation. 2012 Jun;10(1):217-25. https://doi.org/10.1515/hmbci-2012-0006


BibTeX

@article{c823d9cdc10f43baa75c91c08642b28b,
title = "From tissue invasion to glucose metabolism: the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities",
abstract = "UNLABELLED: Abstract Background: The pro-oncogenic transcription factor STAT3 is constitutively active in tumours of many different origins, which often become addicted to its activity. STAT3 is believed to contribute to the initial survival of pre-cancerous cells as well as to hyper-proliferation and, later, metastasis.MATERIALS AND METHODS: To evaluate the contribution of enhanced STAT3 activation in a controlled model system, we generated knock-in mice in which a mutant constitutively active Stat3C allele replaces the endogenous wild-type allele and analysed its contribution to breast tumorigenesis. Moreover, we generated Stat3C/C MEF cells and analysed their gene expression and metabolic profiles.RESULTS: Constitutively active STAT3 could enhance the tumorigenic power of the rat Neu oncogene in MMTV-Neu transgenic mice and trigger the production of earlier onset and more invasive mammary tumours. Tumour-derived cell lines displayed higher migrating, invading and metastatic ability and showed disrupted distribution of cell-cell junction markers. These features were mediated by STAT3-dependent over-expression of the C-terminal tensin-like (Cten) focal adhesion protein. Moreover, STAT3C alone was able to induce aerobic glycolysis and down-regulate mitochondrial activity, both in primary fibroblasts and in STAT3-dependent tumour cell lines, acting via both HIF-1α-dependent and independent mechanisms.CONCLUSIONS: STAT3 can induce a metabolic switch that predisposes cells to aberrant survival, enhanced proliferation and, finally, tumour transformation. Later, enhanced Cten expression contributes to tissue infiltration and metastasis. While not excluding the contribution of many other tumour-specific STAT3 target genes, our data provide a unifying explanation of several pro-oncogenic STAT3 activities.",
author = "Sara Pensa and Marco Demaria and Lidia Avalle and Isaia Barbieri and Annalisa Camporeale and Valeria Poli",
year = "2012",
month = "6",
doi = "10.1515/hmbci-2012-0006",
language = "English",
volume = "10",
pages = "217--25",
journal = "Hormone Molecular Biology and Clinical Investigation",
issn = "1868-1883",
number = "1",

}

RIS

TY - JOUR

T1 - From tissue invasion to glucose metabolism

T2 - the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities

AU - Pensa, Sara

AU - Demaria, Marco

AU - Avalle, Lidia

AU - Barbieri, Isaia

AU - Camporeale, Annalisa

AU - Poli, Valeria

PY - 2012/6

Y1 - 2012/6

N2 - UNLABELLED: Abstract Background: The pro-oncogenic transcription factor STAT3 is constitutively active in tumours of many different origins, which often become addicted to its activity. STAT3 is believed to contribute to the initial survival of pre-cancerous cells as well as to hyper-proliferation and, later, metastasis.MATERIALS AND METHODS: To evaluate the contribution of enhanced STAT3 activation in a controlled model system, we generated knock-in mice in which a mutant constitutively active Stat3C allele replaces the endogenous wild-type allele and analysed its contribution to breast tumorigenesis. Moreover, we generated Stat3C/C MEF cells and analysed their gene expression and metabolic profiles.RESULTS: Constitutively active STAT3 could enhance the tumorigenic power of the rat Neu oncogene in MMTV-Neu transgenic mice and trigger the production of earlier onset and more invasive mammary tumours. Tumour-derived cell lines displayed higher migrating, invading and metastatic ability and showed disrupted distribution of cell-cell junction markers. These features were mediated by STAT3-dependent over-expression of the C-terminal tensin-like (Cten) focal adhesion protein. Moreover, STAT3C alone was able to induce aerobic glycolysis and down-regulate mitochondrial activity, both in primary fibroblasts and in STAT3-dependent tumour cell lines, acting via both HIF-1α-dependent and independent mechanisms.CONCLUSIONS: STAT3 can induce a metabolic switch that predisposes cells to aberrant survival, enhanced proliferation and, finally, tumour transformation. Later, enhanced Cten expression contributes to tissue infiltration and metastasis. While not excluding the contribution of many other tumour-specific STAT3 target genes, our data provide a unifying explanation of several pro-oncogenic STAT3 activities.

AB - UNLABELLED: Abstract Background: The pro-oncogenic transcription factor STAT3 is constitutively active in tumours of many different origins, which often become addicted to its activity. STAT3 is believed to contribute to the initial survival of pre-cancerous cells as well as to hyper-proliferation and, later, metastasis.MATERIALS AND METHODS: To evaluate the contribution of enhanced STAT3 activation in a controlled model system, we generated knock-in mice in which a mutant constitutively active Stat3C allele replaces the endogenous wild-type allele and analysed its contribution to breast tumorigenesis. Moreover, we generated Stat3C/C MEF cells and analysed their gene expression and metabolic profiles.RESULTS: Constitutively active STAT3 could enhance the tumorigenic power of the rat Neu oncogene in MMTV-Neu transgenic mice and trigger the production of earlier onset and more invasive mammary tumours. Tumour-derived cell lines displayed higher migrating, invading and metastatic ability and showed disrupted distribution of cell-cell junction markers. These features were mediated by STAT3-dependent over-expression of the C-terminal tensin-like (Cten) focal adhesion protein. Moreover, STAT3C alone was able to induce aerobic glycolysis and down-regulate mitochondrial activity, both in primary fibroblasts and in STAT3-dependent tumour cell lines, acting via both HIF-1α-dependent and independent mechanisms.CONCLUSIONS: STAT3 can induce a metabolic switch that predisposes cells to aberrant survival, enhanced proliferation and, finally, tumour transformation. Later, enhanced Cten expression contributes to tissue infiltration and metastasis. While not excluding the contribution of many other tumour-specific STAT3 target genes, our data provide a unifying explanation of several pro-oncogenic STAT3 activities.

U2 - 10.1515/hmbci-2012-0006

DO - 10.1515/hmbci-2012-0006

M3 - Article

VL - 10

SP - 217

EP - 225

JO - Hormone Molecular Biology and Clinical Investigation

JF - Hormone Molecular Biology and Clinical Investigation

SN - 1868-1883

IS - 1

ER -

ID: 26938045