Publication

From knemometry to final adult height: Inhaled corticosteroids and their effect on growth in childhood

de Vreede, I., Haarman, E. G., Sprikkelman, A. B. & van Aalderen, W. M., Jun-2013, In : Paediatric respiratory reviews. 14, 2, p. 107-111 5 p.

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  • From knemometry to final adult height Inhaled corticosteroids and their effect on growth in childhood

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DOI

Growth impairment in children with asthma, as a consequence of inhaled corticosteroids (ICS), is a major issue. Adverse systemic effects of ICS have been reviewed extensively, but no clinically relevant effects are reported if they are used in an appropriate dose as advocated in most guidelines. Growth studies can be divided into knemometry studies, intermediate term studies, and long term studies up to final adult height. These different studies provide different information. Knemometry demonstrates a dose dependent systemic effect, while all intermediate term studies demonstrate growth reduction of approximately one cm after one year of treatment. Most reassuring is that this delay seems to be temporary. The one study with a follow-up to final height shows no differences between the ICS and non-ICS treated children. The studies suggest that the use of ICS with respect to growth is safe if these drugs are used in a low to medium dose. (C) 2012 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalPaediatric respiratory reviews
Volume14
Issue number2
Publication statusPublished - Jun-2013
Externally publishedYes

    Keywords

  • Inhaled corticosteroids, Asthma, Height, Child, Side-effects, MILD PERSISTENT ASTHMA, LOW-DOSE CICLESONIDE, TO-MODERATE ASTHMA, LONG-TERM SAFETY, LOWER-LEG GROWTH, FLUTICASONE PROPIONATE, BECLOMETHASONE DIPROPIONATE, PRESCHOOL-CHILDREN, CONTROLLED TRIAL, OPEN-LABEL

ID: 71337077