Publication

From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions

van den Esker, M. H., Kovács, Á. T. & Kuipers, O. P., 5-Dec-2017, In : Mbio. 8, 6, p. 1-5 5 p., e01963-17.

Research output: Contribution to journalArticleAcademicpeer-review

APA

van den Esker, M. H., Kovács, Á. T., & Kuipers, O. P. (2017). From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions. Mbio, 8(6), 1-5. [e01963-17]. https://doi.org/10.1128/mBio.01963-17

Author

van den Esker, Marielle H ; Kovács, Ákos T ; Kuipers, Oscar P. / From Cell Death to Metabolism : Holin-Antiholin Homologues with New Functions. In: Mbio. 2017 ; Vol. 8, No. 6. pp. 1-5.

Harvard

van den Esker, MH, Kovács, ÁT & Kuipers, OP 2017, 'From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions', Mbio, vol. 8, no. 6, e01963-17, pp. 1-5. https://doi.org/10.1128/mBio.01963-17

Standard

From Cell Death to Metabolism : Holin-Antiholin Homologues with New Functions. / van den Esker, Marielle H; Kovács, Ákos T; Kuipers, Oscar P.

In: Mbio, Vol. 8, No. 6, e01963-17, 05.12.2017, p. 1-5.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

van den Esker MH, Kovács ÁT, Kuipers OP. From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions. Mbio. 2017 Dec 5;8(6):1-5. e01963-17. https://doi.org/10.1128/mBio.01963-17


BibTeX

@article{3fa74468eae64445a41e8577bef46946,
title = "From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions",
abstract = "Programmed cell death in bacteria is generally triggered by membrane proteins with functions analogous to those of bacteriophage holins: they disrupt the membrane potential, whereas antiholins antagonize this process. The holin-like class of proteins is present in all three domains of life, but their functions can be different, depending on the species. Using a series of biochemical and genetic approaches, in a recent article in mBio, Charbonnier et al. (mBio 8:e00976-17, 2017, https://doi.org/10.1128/mBio.00976-17) demonstrate that the antiholin homologue in Bacillus subtilis transports pyruvate and is regulated in an unconventional way by its substrate molecule. Here, we discuss the connection between cell death and metabolism in various bacteria carrying genes encoding these holin-antiholin analogues and place the recent study by Charbonnier et al. in an evolutionary context.",
keywords = "Bacillus subtilis, Staphylococcus aureus, antiholin, evolution, holin, metabolism, programmed cell death, pyruvate, BACILLUS-SUBTILIS, BACTERIA, APOPTOSIS, SYSTEMS, LYSIS",
author = "{van den Esker}, {Marielle H} and Kov{\'a}cs, {{\'A}kos T} and Kuipers, {Oscar P}",
note = "Copyright {\textcopyright} 2017 van den Esker et al.",
year = "2017",
month = dec,
day = "5",
doi = "10.1128/mBio.01963-17",
language = "English",
volume = "8",
pages = "1--5",
journal = "Mbio",
issn = "2150-7511",
publisher = "AMER SOC MICROBIOLOGY",
number = "6",

}

RIS

TY - JOUR

T1 - From Cell Death to Metabolism

T2 - Holin-Antiholin Homologues with New Functions

AU - van den Esker, Marielle H

AU - Kovács, Ákos T

AU - Kuipers, Oscar P

N1 - Copyright © 2017 van den Esker et al.

PY - 2017/12/5

Y1 - 2017/12/5

N2 - Programmed cell death in bacteria is generally triggered by membrane proteins with functions analogous to those of bacteriophage holins: they disrupt the membrane potential, whereas antiholins antagonize this process. The holin-like class of proteins is present in all three domains of life, but their functions can be different, depending on the species. Using a series of biochemical and genetic approaches, in a recent article in mBio, Charbonnier et al. (mBio 8:e00976-17, 2017, https://doi.org/10.1128/mBio.00976-17) demonstrate that the antiholin homologue in Bacillus subtilis transports pyruvate and is regulated in an unconventional way by its substrate molecule. Here, we discuss the connection between cell death and metabolism in various bacteria carrying genes encoding these holin-antiholin analogues and place the recent study by Charbonnier et al. in an evolutionary context.

AB - Programmed cell death in bacteria is generally triggered by membrane proteins with functions analogous to those of bacteriophage holins: they disrupt the membrane potential, whereas antiholins antagonize this process. The holin-like class of proteins is present in all three domains of life, but their functions can be different, depending on the species. Using a series of biochemical and genetic approaches, in a recent article in mBio, Charbonnier et al. (mBio 8:e00976-17, 2017, https://doi.org/10.1128/mBio.00976-17) demonstrate that the antiholin homologue in Bacillus subtilis transports pyruvate and is regulated in an unconventional way by its substrate molecule. Here, we discuss the connection between cell death and metabolism in various bacteria carrying genes encoding these holin-antiholin analogues and place the recent study by Charbonnier et al. in an evolutionary context.

KW - Bacillus subtilis

KW - Staphylococcus aureus

KW - antiholin

KW - evolution

KW - holin

KW - metabolism

KW - programmed cell death

KW - pyruvate

KW - BACILLUS-SUBTILIS

KW - BACTERIA

KW - APOPTOSIS

KW - SYSTEMS

KW - LYSIS

U2 - 10.1128/mBio.01963-17

DO - 10.1128/mBio.01963-17

M3 - Article

C2 - 29208748

VL - 8

SP - 1

EP - 5

JO - Mbio

JF - Mbio

SN - 2150-7511

IS - 6

M1 - e01963-17

ER -

ID: 51452353