From Biological Cilia to Artificial Flow Sensors: Biomimetic Soft Polymer Nanosensors with High Sensing PerformanceAsadnia, M., Kottapalli, A. G. P., Karavitaki, K. D., Warkiani, M. E., Miao, J., Corey, D. P. & Triantafyllou, M., 13-Sep-2016, In : Scientific Reports. 6, 13 p., 32955.
Research output: Contribution to journal › Article › Academic › peer-review
We report the development of a new class of miniature all-polymer flow sensors that closely mimic the intricate morphology of the mechanosensory ciliary bundles in biological hair cells. An artificial ciliary bundle is achieved by fabricating bundled polydimethylsiloxane (PDMS) micro-pillars with graded heights and electrospinning polyvinylidenefluoride (PVDF) piezoelectric nanofiber tip links. The piezoelectric nature of a single nanofiber tip link is confirmed by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). Rheology and nanoindentation experiments are used to ensure that the viscous properties of the hyaluronic acid (HA)-based hydrogel are close to the biological cupula. A dome-shaped HA hydrogel cupula that encapsulates the artificial hair cell bundle is formed through precision drop-casting and swelling processes. Fluid drag force actuates the hydrogel cupula and deflects the micro-pillar bundle, stretching the nanofibers and generating electric charges. Functioning with principles analogous to the hair bundles, the sensors achieve a sensitivity and threshold detection limit of 300 mV/(m/s) and 8 mu m/s, respectively. These self-powered, sensitive, flexible, biocompatibale and miniaturized sensors can find extensive applications in navigation and maneuvering of underwater robots, artificial hearing systems, biomedical and microfluidic devices.
|Number of pages||13|
|Publication status||Published - 13-Sep-2016|
- POSTERIOR LATERAL-LINE, VERTEBRATE HAIR-CELLS, FREQUENCY-RESPONSE, LARVAL ZEBRAFISH, MOTTLED SCULPIN, DANIO-RERIO, CROSS-LINKS, TRANSDUCTION, SENSITIVITY, SYSTEM