Publication

FRI0277 ANTI-SSA antibody status in combination with ultrasound of major salivary glands: a shortcut in the classification of primary sjÖgren's syndrome?

Mossel, E., Delli, K., Van Nimwegen, J. F., Stel, A. J., Kroese, F. G. M., Spijkervet, F. K. L., Vissink, A., Arends, S., Bootsma, H. & EULAR US-pSS Study Grp, Jun-2017, In : Annals of the Rheumatic Diseases. 76, p. 591-591 1 p.

Research output: Contribution to journalMeeting AbstractAcademic

APA

Mossel, E., Delli, K., Van Nimwegen, J. F., Stel, A. J., Kroese, F. G. M., Spijkervet, F. K. L., ... EULAR US-pSS Study Grp (2017). FRI0277 ANTI-SSA antibody status in combination with ultrasound of major salivary glands: a shortcut in the classification of primary sjÖgren's syndrome? Annals of the Rheumatic Diseases, 76, 591-591. https://doi.org/10.1136/annrheumdis-2017-eular.5938

Author

Mossel, E. ; Delli, K. ; Van Nimwegen, J. F. ; Stel, A. J. ; Kroese, F. G. M. ; Spijkervet, F. K. L. ; Vissink, A. ; Arends, S. ; Bootsma, H. ; EULAR US-pSS Study Grp. / FRI0277 ANTI-SSA antibody status in combination with ultrasound of major salivary glands : a shortcut in the classification of primary sjÖgren's syndrome?. In: Annals of the Rheumatic Diseases. 2017 ; Vol. 76. pp. 591-591.

Harvard

Mossel, E, Delli, K, Van Nimwegen, JF, Stel, AJ, Kroese, FGM, Spijkervet, FKL, Vissink, A, Arends, S, Bootsma, H & EULAR US-pSS Study Grp 2017, 'FRI0277 ANTI-SSA antibody status in combination with ultrasound of major salivary glands: a shortcut in the classification of primary sjÖgren's syndrome?', Annals of the Rheumatic Diseases, vol. 76, pp. 591-591. https://doi.org/10.1136/annrheumdis-2017-eular.5938

Standard

FRI0277 ANTI-SSA antibody status in combination with ultrasound of major salivary glands : a shortcut in the classification of primary sjÖgren's syndrome? / Mossel, E.; Delli, K.; Van Nimwegen, J. F.; Stel, A. J.; Kroese, F. G. M.; Spijkervet, F. K. L.; Vissink, A.; Arends, S.; Bootsma, H.; EULAR US-pSS Study Grp.

In: Annals of the Rheumatic Diseases, Vol. 76, 06.2017, p. 591-591.

Research output: Contribution to journalMeeting AbstractAcademic

Vancouver

Mossel E, Delli K, Van Nimwegen JF, Stel AJ, Kroese FGM, Spijkervet FKL et al. FRI0277 ANTI-SSA antibody status in combination with ultrasound of major salivary glands: a shortcut in the classification of primary sjÖgren's syndrome? Annals of the Rheumatic Diseases. 2017 Jun;76:591-591. https://doi.org/10.1136/annrheumdis-2017-eular.5938


BibTeX

@article{5c1b50be5eff4c1fa06f5914c6926cc9,
title = "FRI0277 ANTI-SSA antibody status in combination with ultrasound of major salivary glands: a shortcut in the classification of primary sj{\"O}gren's syndrome?",
abstract = "Background Ultrasound of major salivary glands (sUS) is an upcoming diagnostic method to assess the involvement of major salivary glands in primary Sj{\"o}gren's syndrome (pSS). In the AECG, ACR and recently published ACR-EULAR criteria, a positive salivary gland biopsy and/or presence of anti-SSA antibodies are necessary to classify a patient as pSS, while sUS is not included as a diagnostic item.Objectives To assess whether combining anti-SSA antibody status with sUS outcome can predict classification of patients as pSS in our inception cohort study.Methods Consecutive outpatients clinically suspected with pSS underwent sUS of the parotid and submandibular glands. Parenchymal echogenicity, homogeneity, hypoechogenic areas, hyperechogenic reflections and clearness of salivary gland border were scored according to the Hocevar scoring system (total score 0–48).1 Positive sUS was defined as total score ≥15. Patients underwent a diagnostic work up according to the AECG, ACR and ACR-EULAR criteria. We analyzed the predictive value of the combination of anti-SSA antibody status and sUS outcome for classification as pSS or non-pSS. Separate analyses were done considering either i) parotid gland biopsy or ii) labial gland biopsy as an item, when applying these classification criteria.Results Anti-SSA antibody status was positive in 53 (51{\%}) patients and sUS was positive in 40 (39{\%}) patients.When parotid gland biopsy outcome was considered as an item of the criteria, 45 of 97 patients were classified as pSS according to the AECG, 44 of 97 according to the ACR and 52 of 99 according to the ACR-EULAR criteria. The combination of presence of anti-SSA antibodies with positive sUS showed a very high positive predictive value for classification as pSS (94–97{\%}) and the combination of absence of anti-SSA antibodies with negative sUS highly excludes classification (negative predictive value 98–100{\%}).When labial gland biopsy outcome was considered as an item of the criteria, 49 of 96 patients were classified as pSS according to the AECG, 43 of 93 according to the ACR and 55 of 97 according to the ACR-EULAR criteria. The combination of presence of anti-SSA antibodies with positive sUS showed a high positive predictive value for classification as pSS (94–97{\%}). However, the combination of absence of anti-SSA antibodies with negative sUS did not per se exclude classification (negative predictive value 89–93{\%}).Conclusions In our prospective inception cohort study derived from daily clinical practice, the combination of presence of anti-SSA antibodies and positive sUS outcome highly predicts classification as pSS according to the AECG, ACR and ACR-EULAR classification criteria.",
author = "E. Mossel and K. Delli and {Van Nimwegen}, {J. F.} and Stel, {A. J.} and Kroese, {F. G. M.} and Spijkervet, {F. K. L.} and A. Vissink and S. Arends and H. Bootsma and {EULAR US-pSS Study Grp}",
year = "2017",
month = "6",
doi = "10.1136/annrheumdis-2017-eular.5938",
language = "English",
volume = "76",
pages = "591--591",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "BMJ PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - FRI0277 ANTI-SSA antibody status in combination with ultrasound of major salivary glands

T2 - a shortcut in the classification of primary sjÖgren's syndrome?

AU - Mossel, E.

AU - Delli, K.

AU - Van Nimwegen, J. F.

AU - Stel, A. J.

AU - Kroese, F. G. M.

AU - Spijkervet, F. K. L.

AU - Vissink, A.

AU - Arends, S.

AU - Bootsma, H.

AU - EULAR US-pSS Study Grp

PY - 2017/6

Y1 - 2017/6

N2 - Background Ultrasound of major salivary glands (sUS) is an upcoming diagnostic method to assess the involvement of major salivary glands in primary Sjögren's syndrome (pSS). In the AECG, ACR and recently published ACR-EULAR criteria, a positive salivary gland biopsy and/or presence of anti-SSA antibodies are necessary to classify a patient as pSS, while sUS is not included as a diagnostic item.Objectives To assess whether combining anti-SSA antibody status with sUS outcome can predict classification of patients as pSS in our inception cohort study.Methods Consecutive outpatients clinically suspected with pSS underwent sUS of the parotid and submandibular glands. Parenchymal echogenicity, homogeneity, hypoechogenic areas, hyperechogenic reflections and clearness of salivary gland border were scored according to the Hocevar scoring system (total score 0–48).1 Positive sUS was defined as total score ≥15. Patients underwent a diagnostic work up according to the AECG, ACR and ACR-EULAR criteria. We analyzed the predictive value of the combination of anti-SSA antibody status and sUS outcome for classification as pSS or non-pSS. Separate analyses were done considering either i) parotid gland biopsy or ii) labial gland biopsy as an item, when applying these classification criteria.Results Anti-SSA antibody status was positive in 53 (51%) patients and sUS was positive in 40 (39%) patients.When parotid gland biopsy outcome was considered as an item of the criteria, 45 of 97 patients were classified as pSS according to the AECG, 44 of 97 according to the ACR and 52 of 99 according to the ACR-EULAR criteria. The combination of presence of anti-SSA antibodies with positive sUS showed a very high positive predictive value for classification as pSS (94–97%) and the combination of absence of anti-SSA antibodies with negative sUS highly excludes classification (negative predictive value 98–100%).When labial gland biopsy outcome was considered as an item of the criteria, 49 of 96 patients were classified as pSS according to the AECG, 43 of 93 according to the ACR and 55 of 97 according to the ACR-EULAR criteria. The combination of presence of anti-SSA antibodies with positive sUS showed a high positive predictive value for classification as pSS (94–97%). However, the combination of absence of anti-SSA antibodies with negative sUS did not per se exclude classification (negative predictive value 89–93%).Conclusions In our prospective inception cohort study derived from daily clinical practice, the combination of presence of anti-SSA antibodies and positive sUS outcome highly predicts classification as pSS according to the AECG, ACR and ACR-EULAR classification criteria.

AB - Background Ultrasound of major salivary glands (sUS) is an upcoming diagnostic method to assess the involvement of major salivary glands in primary Sjögren's syndrome (pSS). In the AECG, ACR and recently published ACR-EULAR criteria, a positive salivary gland biopsy and/or presence of anti-SSA antibodies are necessary to classify a patient as pSS, while sUS is not included as a diagnostic item.Objectives To assess whether combining anti-SSA antibody status with sUS outcome can predict classification of patients as pSS in our inception cohort study.Methods Consecutive outpatients clinically suspected with pSS underwent sUS of the parotid and submandibular glands. Parenchymal echogenicity, homogeneity, hypoechogenic areas, hyperechogenic reflections and clearness of salivary gland border were scored according to the Hocevar scoring system (total score 0–48).1 Positive sUS was defined as total score ≥15. Patients underwent a diagnostic work up according to the AECG, ACR and ACR-EULAR criteria. We analyzed the predictive value of the combination of anti-SSA antibody status and sUS outcome for classification as pSS or non-pSS. Separate analyses were done considering either i) parotid gland biopsy or ii) labial gland biopsy as an item, when applying these classification criteria.Results Anti-SSA antibody status was positive in 53 (51%) patients and sUS was positive in 40 (39%) patients.When parotid gland biopsy outcome was considered as an item of the criteria, 45 of 97 patients were classified as pSS according to the AECG, 44 of 97 according to the ACR and 52 of 99 according to the ACR-EULAR criteria. The combination of presence of anti-SSA antibodies with positive sUS showed a very high positive predictive value for classification as pSS (94–97%) and the combination of absence of anti-SSA antibodies with negative sUS highly excludes classification (negative predictive value 98–100%).When labial gland biopsy outcome was considered as an item of the criteria, 49 of 96 patients were classified as pSS according to the AECG, 43 of 93 according to the ACR and 55 of 97 according to the ACR-EULAR criteria. The combination of presence of anti-SSA antibodies with positive sUS showed a high positive predictive value for classification as pSS (94–97%). However, the combination of absence of anti-SSA antibodies with negative sUS did not per se exclude classification (negative predictive value 89–93%).Conclusions In our prospective inception cohort study derived from daily clinical practice, the combination of presence of anti-SSA antibodies and positive sUS outcome highly predicts classification as pSS according to the AECG, ACR and ACR-EULAR classification criteria.

U2 - 10.1136/annrheumdis-2017-eular.5938

DO - 10.1136/annrheumdis-2017-eular.5938

M3 - Meeting Abstract

VL - 76

SP - 591

EP - 591

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

ER -

ID: 50357396