Publication

Fourteen-Year Follow-Up From CABADAS: Vitamin K Antagonists or Dipyridamole Not Superior to Aspirin

Veeger, N. J. G. M., Zijlstra, F., Hillege, H. L., van der Meer, J. & Interuniv Cardiology Inst Netherla, Nov-2010, In : Annals of thoracic surgery. 90, 5, p. 1515-U527 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Veeger, N. J. G. M., Zijlstra, F., Hillege, H. L., van der Meer, J., & Interuniv Cardiology Inst Netherla (2010). Fourteen-Year Follow-Up From CABADAS: Vitamin K Antagonists or Dipyridamole Not Superior to Aspirin. Annals of thoracic surgery, 90(5), 1515-U527. https://doi.org/10.1016/j.athoracsur.2010.06.007

Author

Veeger, Nic J. G. M. ; Zijlstra, Felix ; Hillege, Hans L. ; van der Meer, Jan ; Interuniv Cardiology Inst Netherla. / Fourteen-Year Follow-Up From CABADAS : Vitamin K Antagonists or Dipyridamole Not Superior to Aspirin. In: Annals of thoracic surgery. 2010 ; Vol. 90, No. 5. pp. 1515-U527.

Harvard

Veeger, NJGM, Zijlstra, F, Hillege, HL, van der Meer, J & Interuniv Cardiology Inst Netherla 2010, 'Fourteen-Year Follow-Up From CABADAS: Vitamin K Antagonists or Dipyridamole Not Superior to Aspirin', Annals of thoracic surgery, vol. 90, no. 5, pp. 1515-U527. https://doi.org/10.1016/j.athoracsur.2010.06.007

Standard

Fourteen-Year Follow-Up From CABADAS : Vitamin K Antagonists or Dipyridamole Not Superior to Aspirin. / Veeger, Nic J. G. M.; Zijlstra, Felix; Hillege, Hans L.; van der Meer, Jan; Interuniv Cardiology Inst Netherla.

In: Annals of thoracic surgery, Vol. 90, No. 5, 11.2010, p. 1515-U527.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Veeger NJGM, Zijlstra F, Hillege HL, van der Meer J, Interuniv Cardiology Inst Netherla. Fourteen-Year Follow-Up From CABADAS: Vitamin K Antagonists or Dipyridamole Not Superior to Aspirin. Annals of thoracic surgery. 2010 Nov;90(5):1515-U527. https://doi.org/10.1016/j.athoracsur.2010.06.007


BibTeX

@article{65a426a81376413cbb4a18c7742d21ed,
title = "Fourteen-Year Follow-Up From CABADAS: Vitamin K Antagonists or Dipyridamole Not Superior to Aspirin",
abstract = "Background. Secondary prophylaxis using aspirin is standard of care after coronary artery bypass graft surgery. Limited data are available for long-term results. We evaluated the effect of aspirin, aspirin with dipyridamole, and vitamin K antagonists (VKA) on 14-year clinical outcome of patients included in the Prevention of Coronary Artery Bypass Graft Occlusion by Aspirin, Dipyridamole, and Acenocoumarol/Phenprocoumon Study (CABADAS).Methods. All 726 Dutch patients for whom antithrombotic therapy with aspirin (n = 248), aspirin with dipyridamole (n = 234), or VKA (n = 244) was randomly allocated were included. The primary endpoint was occurrence of major adverse cardiac events (MACE). Outcomes were retrospectively evaluated during 14-year follow-up.Results. Cumulative incidences for MACE over 14 years were 49%, 50%, and 59% for patients treated with aspirin, aspirin with dipyridamole, and VKA, respectively. Although the overall occurrence of MACE did not significantly differ among the three treatment groups (p = 0.12), patients treated with VKA were at higher risk of MACE than patients treated with aspirin with dipyridamole (hazard ratio 1.3, 95% confidence interval: 1.0 to 1.8, p = 0.041) and patients treated with aspirin alone (hazard ratio 1.1, 95% confidence interval: 0.86 to 1.5, p = 0.37). This difference was attributed to an increased risk of repeat revascularization in patients treated with VKA, without any differences in cardiac death and myocardial infarction among the three treatment groups. However, the observed high rate of repeat revascularization in patients treated with VKA could reflect an a priori increased probability for repeat revascularization due to the specific conditions surrounding VKA therapy (ie, more intense patient-doctor contacts).Conclusions. This study with 14-year clinical outcome provides further evidence for the use of aspirin as secondary prophylaxis after coronary artery bypass graft surgery. (Ann Thorac Surg 2010;90:1515-22) (C) 2010 by The Society of Thoracic Surgeons",
keywords = "LOW-DOSE ASPIRIN, CORONARY-BYPASS SURGERY, MULTIVESSEL DISEASE, PLUS DIPYRIDAMOLE, RANDOMIZED-TRIAL, GRAFT PATENCY, PREVENTION, AGENTS, ARTS",
author = "Veeger, {Nic J. G. M.} and Felix Zijlstra and Hillege, {Hans L.} and {van der Meer}, Jan and {Interuniv Cardiology Inst Netherla}",
year = "2010",
month = nov,
doi = "10.1016/j.athoracsur.2010.06.007",
language = "English",
volume = "90",
pages = "1515--U527",
journal = "Annals of thoracic surgery",
issn = "0003-4975",
publisher = "ELSEVIER SCIENCE INC",
number = "5",

}

RIS

TY - JOUR

T1 - Fourteen-Year Follow-Up From CABADAS

T2 - Vitamin K Antagonists or Dipyridamole Not Superior to Aspirin

AU - Veeger, Nic J. G. M.

AU - Zijlstra, Felix

AU - Hillege, Hans L.

AU - van der Meer, Jan

AU - Interuniv Cardiology Inst Netherla

PY - 2010/11

Y1 - 2010/11

N2 - Background. Secondary prophylaxis using aspirin is standard of care after coronary artery bypass graft surgery. Limited data are available for long-term results. We evaluated the effect of aspirin, aspirin with dipyridamole, and vitamin K antagonists (VKA) on 14-year clinical outcome of patients included in the Prevention of Coronary Artery Bypass Graft Occlusion by Aspirin, Dipyridamole, and Acenocoumarol/Phenprocoumon Study (CABADAS).Methods. All 726 Dutch patients for whom antithrombotic therapy with aspirin (n = 248), aspirin with dipyridamole (n = 234), or VKA (n = 244) was randomly allocated were included. The primary endpoint was occurrence of major adverse cardiac events (MACE). Outcomes were retrospectively evaluated during 14-year follow-up.Results. Cumulative incidences for MACE over 14 years were 49%, 50%, and 59% for patients treated with aspirin, aspirin with dipyridamole, and VKA, respectively. Although the overall occurrence of MACE did not significantly differ among the three treatment groups (p = 0.12), patients treated with VKA were at higher risk of MACE than patients treated with aspirin with dipyridamole (hazard ratio 1.3, 95% confidence interval: 1.0 to 1.8, p = 0.041) and patients treated with aspirin alone (hazard ratio 1.1, 95% confidence interval: 0.86 to 1.5, p = 0.37). This difference was attributed to an increased risk of repeat revascularization in patients treated with VKA, without any differences in cardiac death and myocardial infarction among the three treatment groups. However, the observed high rate of repeat revascularization in patients treated with VKA could reflect an a priori increased probability for repeat revascularization due to the specific conditions surrounding VKA therapy (ie, more intense patient-doctor contacts).Conclusions. This study with 14-year clinical outcome provides further evidence for the use of aspirin as secondary prophylaxis after coronary artery bypass graft surgery. (Ann Thorac Surg 2010;90:1515-22) (C) 2010 by The Society of Thoracic Surgeons

AB - Background. Secondary prophylaxis using aspirin is standard of care after coronary artery bypass graft surgery. Limited data are available for long-term results. We evaluated the effect of aspirin, aspirin with dipyridamole, and vitamin K antagonists (VKA) on 14-year clinical outcome of patients included in the Prevention of Coronary Artery Bypass Graft Occlusion by Aspirin, Dipyridamole, and Acenocoumarol/Phenprocoumon Study (CABADAS).Methods. All 726 Dutch patients for whom antithrombotic therapy with aspirin (n = 248), aspirin with dipyridamole (n = 234), or VKA (n = 244) was randomly allocated were included. The primary endpoint was occurrence of major adverse cardiac events (MACE). Outcomes were retrospectively evaluated during 14-year follow-up.Results. Cumulative incidences for MACE over 14 years were 49%, 50%, and 59% for patients treated with aspirin, aspirin with dipyridamole, and VKA, respectively. Although the overall occurrence of MACE did not significantly differ among the three treatment groups (p = 0.12), patients treated with VKA were at higher risk of MACE than patients treated with aspirin with dipyridamole (hazard ratio 1.3, 95% confidence interval: 1.0 to 1.8, p = 0.041) and patients treated with aspirin alone (hazard ratio 1.1, 95% confidence interval: 0.86 to 1.5, p = 0.37). This difference was attributed to an increased risk of repeat revascularization in patients treated with VKA, without any differences in cardiac death and myocardial infarction among the three treatment groups. However, the observed high rate of repeat revascularization in patients treated with VKA could reflect an a priori increased probability for repeat revascularization due to the specific conditions surrounding VKA therapy (ie, more intense patient-doctor contacts).Conclusions. This study with 14-year clinical outcome provides further evidence for the use of aspirin as secondary prophylaxis after coronary artery bypass graft surgery. (Ann Thorac Surg 2010;90:1515-22) (C) 2010 by The Society of Thoracic Surgeons

KW - LOW-DOSE ASPIRIN

KW - CORONARY-BYPASS SURGERY

KW - MULTIVESSEL DISEASE

KW - PLUS DIPYRIDAMOLE

KW - RANDOMIZED-TRIAL

KW - GRAFT PATENCY

KW - PREVENTION

KW - AGENTS

KW - ARTS

U2 - 10.1016/j.athoracsur.2010.06.007

DO - 10.1016/j.athoracsur.2010.06.007

M3 - Article

VL - 90

SP - 1515-U527

JO - Annals of thoracic surgery

JF - Annals of thoracic surgery

SN - 0003-4975

IS - 5

ER -

ID: 5189146