Fourfold symmetric MCR's via the tetraisocyanide 1,3-diisocyano-2,2-bis(isocyanomethyl)propane

Butera, R., Shrinidhi, A., Kurpiewska, K., Kalinowska-Tłuścik, J. & Dömling, A., 15-Sep-2020, In : Chemical communications (Cambridge, England). 56, 73, p. 10662-10665 4 p.

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Oligoisocyanides are attractive synthetic targets, however, only a few are known. Here, we describe the smallest stable tetraisocyanide possible, the 1,3-diisocyano-2,2-bis(isocyano-methyl)propane (1) with S4 symmetry. Its four-step synthesis, structure, and reactivity in unprecedented symmetric fourfold Ugi 4CR and fourfold Passerini 3CR are described. Exhibiting high functional group tolerance and moderate to high yields, we foresee multiple applications of 1,3-diisocyano-2,2-bis(isocyanomethyl)propane, for example in MOFs, COFs, dendrimers, or artificial organs.

Original languageEnglish
Pages (from-to)10662-10665
Number of pages4
JournalChemical communications (Cambridge, England)
Issue number73
Publication statusPublished - 15-Sep-2020

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