Folding and replication in complex dynamic molecular networks

Liu, B., 2019, [Groningen]: University of Groningen. 228 p.

Research output: ThesisThesis fully internal (DIV)Academic

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  • Title and contents

    Final publisher's version, 442 KB, PDF document

  • Chapter 1

    Final publisher's version, 2 MB, PDF document

  • Chapter 2

    Final publisher's version, 3 MB, PDF document

  • Chapter 3

    Final publisher's version, 8 MB, PDF document

  • Chapter 4

    Final publisher's version, 16 MB, PDF document

  • Chapter 5

    Final publisher's version, 3 MB, PDF document

  • Chapter 6

    Final publisher's version, 196 KB, PDF document

  • Summary

    Final publisher's version, 380 KB, PDF document

  • Samenvatting

    Final publisher's version, 378 KB, PDF document

  • Acknowledgements

    Final publisher's version, 128 KB, PDF document

  • Complete thesis

    Final publisher's version, 34 MB, PDF document

  • Propositions

    Final publisher's version, 106 KB, PDF document


  • Bin Liu
This thesis intends to capture the processes of self-replication and folding individually or combined by using dynamic combinatorial chemistry. This thesis is composed of 6 chapters, each of them dealing with a different aspect of folding and replication.
In Chapter 1, we briefly introduced the basic concepts of systems chemistry and the origin of life. In order to mimic some of life’s important features and to achieve life-like behavior, it is particularly important to construct complex systems that combine the processes of self-replication and folding. In Chapter 2, we described how a dynamic combinatorial selection approach allows access to a foldamer of remarkable complexity constituted by 15 identical peptide-nucleobase building blocks. In Chapter 3, we reported the discovery of foldamers that form autonomously in aqueous media based on simple dipeptides using a systems chemistry approach. In Chapter 4, we described the emergence of self-replicating molecules that contain both amino acids and nucleobase from DCLs. In Chapter 5 we described for the first time the self-sorting between self-replicating and folded molecules in a DCL composed of two building blocks. Furthermore, we developed a transient self-replicating system using the same building blocks. Conclusions are drawn in Chapter 6.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Otto, Sijbren, Supervisor
  • Roelfes, G., Supervisor, External person
  • Guichard, G., Assessment committee, External person
  • Brunsveld, Luc, Assessment committee, External person
  • Browne, Wesley, Assessment committee
Award date29-Oct-2019
Place of Publication[Groningen]
Print ISBNs978-94-034-2086-8
Electronic ISBNs978-94-034-2085-1
Publication statusPublished - 2019

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