Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomographyArif, W. M., Elsinga, P. H., Gasca-Salas, C., Versluis, M., Martínez-Fernández, R., Dierckx, R. A. J. O., Borra, R. J. H. & Luurtsema, G., 10-Aug-2020, In : Journal of controlled release : official journal of the Controlled Release Society. 324, p. 303-316 14 p.
Research output: Contribution to journal › Review article › Academic › peer-review
Focused ultrasound (FUS) is a minimally-invasive technology used for treatment of many diseases, including diseases related to the colon, uterus, prostate, and brain. Although it has been mainly used for ablative procedures, the ability of FUS to open the blood-brain barrier (BBB) presents a promising new application. However, the mechanism of BBB opening by FUS remains unclear. This review focuses on the use of FUS to open the BBB for enhancing drug delivery and investigating how Positron Emission Tomography (PET) provides insight into the underlying mechanism.
|Number of pages||14|
|Journal||Journal of controlled release : official journal of the Controlled Release Society|
|Early online date||16-May-2020|
|Publication status||Published - 10-Aug-2020|
- FUS, microbubbles, RADIOTRACER, BBB transporters
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