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Flavoprotein oxidases: classification and applications

Dijkman, W. P., de Gonzalo, G., Mattevi, A. & Fraaije, M. W., Jun-2013, In : Applied Microbiology and Biotechnology. 97, 12, p. 5177-5188 12 p.

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DOI

This review provides an overview of oxidases that utilise a flavin cofactor for catalysis. This class of oxidative flavoenzymes has shown to harbour a large number of biotechnologically interesting enzymes. Applications range from their use as biocatalysts for the synthesis of pharmaceutical compounds to the integration in biosensors. Through the recent developments in genome sequencing, the number of newly discovered oxidases is steadily growing. Recent progress in the field of flavoprotein oxidase discovery and the obtained biochemical knowledge on these enzymes are reviewed. Except for a structure-based classification of known flavoprotein oxidases, also their potential in recent biotechnological applications is discussed.

Original languageEnglish
Pages (from-to)5177-5188
Number of pages12
JournalApplied Microbiology and Biotechnology
Volume97
Issue number12
Publication statusPublished - Jun-2013

    Keywords

  • Flavoproteins, Oxidases, Biocatalysis, Biosensors, Flavin, Oxygen, VANILLYL-ALCOHOL OXIDASE, BERBERINE BRIDGE ENZYME, D-AMINO-ACID, SUBSTRATE-SPECIFICITY, CRYSTAL-STRUCTURE, PENICILLIUM-SIMPLICISSIMUM, LACTOBACILLUS-PLANTARUM, XANTHINE DEHYDROGENASE, THIAMIN DIPHOSPHATE, AEROCOCCUS-VIRIDANS

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