Publication

Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients

Sotomayor, C. G., Gomes-Neto, A. W., Gans, R. O. B., de Borst, M. H., Berger, S. P., Rodrigo, R., Navis, G. J., Touw, D. J. & Bakker, S. J. L., Oct-2018, In : Nutrients. 10, 10, 15 p., 1419.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Sotomayor, C. G., Gomes-Neto, A. W., Gans, R. O. B., de Borst, M. H., Berger, S. P., Rodrigo, R., ... Bakker, S. J. L. (2018). Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients. Nutrients, 10(10), [1419]. https://doi.org/10.3390/nu10101419

Author

Sotomayor, Camilo G. ; Gomes-Neto, Antonio W. ; Gans, Rijk O. B. ; de Borst, Martin H. ; Berger, Stefan P. ; Rodrigo, Ramon ; Navis, Gerjan J. ; Touw, Daan J. ; Bakker, Stephan J. L. / Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients. In: Nutrients. 2018 ; Vol. 10, No. 10.

Harvard

Sotomayor, CG, Gomes-Neto, AW, Gans, ROB, de Borst, MH, Berger, SP, Rodrigo, R, Navis, GJ, Touw, DJ & Bakker, SJL 2018, 'Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients', Nutrients, vol. 10, no. 10, 1419. https://doi.org/10.3390/nu10101419

Standard

Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients. / Sotomayor, Camilo G.; Gomes-Neto, Antonio W.; Gans, Rijk O. B.; de Borst, Martin H.; Berger, Stefan P.; Rodrigo, Ramon; Navis, Gerjan J.; Touw, Daan J.; Bakker, Stephan J. L.

In: Nutrients, Vol. 10, No. 10, 1419, 10.2018.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Sotomayor CG, Gomes-Neto AW, Gans ROB, de Borst MH, Berger SP, Rodrigo R et al. Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients. Nutrients. 2018 Oct;10(10). 1419. https://doi.org/10.3390/nu10101419


BibTeX

@article{b6328b4943a44f5692cdc2f4bf40f17d,
title = "Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients",
abstract = "Marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFAs) are inversely associated with cardiovascular and all-cause mortality in renal transplant recipients (RTRs). Recommendations to increase marine-derived n-3 PUFAs by increasing fish intake may have a drawback in concomitant stimulation of mercury intake, which could lead to higher circulating mercury concentrations and mitigation of otherwise beneficial effects of n-3 PUFAs. We aimed to monitor circulating mercury concentrations, and to prospectively evaluate whether it counteracts the potential association between fish intake and cardiovascular and all-cause mortality in a cohort of RTRs (n = 604, 53 +/- 13 years-old, 57{\%} men) with long-term follow-up (median of 5.4 years; 121 deaths). Circulating mercury concentration (median 0.30 (IQR 0.14-0.63) mu g/L) positively associated with fish intake (std. beta = 0.21, p <0.001). Multivariable-adjusted Cox-proportional hazards regression analyses showed that prior to, and after additional adjustment for circulating mercury concentrations, fish intake was inversely associated with both cardiovascular (HR 0.75, 95{\%} CI 0.58-0.96; and, HR 0.75, 95{\%} CI 0.58-0.97, respectively) and all-cause mortality (HR 0.84, 95{\%} CI 0.72-0.97; and, HR 0.86, 95{\%} CI 0.74-0.99, respectively). Secondary analyses accounting for marine-derived n-3 PUFAs intake revealed associations of similar magnitude. In conclusion, we found no evidence of a counteracting effect conferred by circulating mercury concentrations on the associations between fish and marine-derived n-3 PUFAs intake and the risks of cardiovascular and all-cause mortality in RTRs.",
keywords = "fish intake, omega-3 polyunsaturated fatty acids, mercury, cardiovascular mortality, all-cause mortality, renal transplant recipients, AMERICAN-HEART-ASSOCIATION, N-3 FATTY-ACIDS, CARDIOVASCULAR-DISEASE, VENTRICULAR MYOCARDIUM, IN-VITRO, RISK, OMEGA-3-FATTY-ACIDS, CONSUMPTION, PREVENTION, SURVIVAL",
author = "Sotomayor, {Camilo G.} and Gomes-Neto, {Antonio W.} and Gans, {Rijk O. B.} and {de Borst}, {Martin H.} and Berger, {Stefan P.} and Ramon Rodrigo and Navis, {Gerjan J.} and Touw, {Daan J.} and Bakker, {Stephan J. L.}",
year = "2018",
month = "10",
doi = "10.3390/nu10101419",
language = "English",
volume = "10",
journal = "Nutrients",
issn = "2072-6643",
publisher = "MDPI AG",
number = "10",

}

RIS

TY - JOUR

T1 - Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients

AU - Sotomayor, Camilo G.

AU - Gomes-Neto, Antonio W.

AU - Gans, Rijk O. B.

AU - de Borst, Martin H.

AU - Berger, Stefan P.

AU - Rodrigo, Ramon

AU - Navis, Gerjan J.

AU - Touw, Daan J.

AU - Bakker, Stephan J. L.

PY - 2018/10

Y1 - 2018/10

N2 - Marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFAs) are inversely associated with cardiovascular and all-cause mortality in renal transplant recipients (RTRs). Recommendations to increase marine-derived n-3 PUFAs by increasing fish intake may have a drawback in concomitant stimulation of mercury intake, which could lead to higher circulating mercury concentrations and mitigation of otherwise beneficial effects of n-3 PUFAs. We aimed to monitor circulating mercury concentrations, and to prospectively evaluate whether it counteracts the potential association between fish intake and cardiovascular and all-cause mortality in a cohort of RTRs (n = 604, 53 +/- 13 years-old, 57% men) with long-term follow-up (median of 5.4 years; 121 deaths). Circulating mercury concentration (median 0.30 (IQR 0.14-0.63) mu g/L) positively associated with fish intake (std. beta = 0.21, p <0.001). Multivariable-adjusted Cox-proportional hazards regression analyses showed that prior to, and after additional adjustment for circulating mercury concentrations, fish intake was inversely associated with both cardiovascular (HR 0.75, 95% CI 0.58-0.96; and, HR 0.75, 95% CI 0.58-0.97, respectively) and all-cause mortality (HR 0.84, 95% CI 0.72-0.97; and, HR 0.86, 95% CI 0.74-0.99, respectively). Secondary analyses accounting for marine-derived n-3 PUFAs intake revealed associations of similar magnitude. In conclusion, we found no evidence of a counteracting effect conferred by circulating mercury concentrations on the associations between fish and marine-derived n-3 PUFAs intake and the risks of cardiovascular and all-cause mortality in RTRs.

AB - Marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFAs) are inversely associated with cardiovascular and all-cause mortality in renal transplant recipients (RTRs). Recommendations to increase marine-derived n-3 PUFAs by increasing fish intake may have a drawback in concomitant stimulation of mercury intake, which could lead to higher circulating mercury concentrations and mitigation of otherwise beneficial effects of n-3 PUFAs. We aimed to monitor circulating mercury concentrations, and to prospectively evaluate whether it counteracts the potential association between fish intake and cardiovascular and all-cause mortality in a cohort of RTRs (n = 604, 53 +/- 13 years-old, 57% men) with long-term follow-up (median of 5.4 years; 121 deaths). Circulating mercury concentration (median 0.30 (IQR 0.14-0.63) mu g/L) positively associated with fish intake (std. beta = 0.21, p <0.001). Multivariable-adjusted Cox-proportional hazards regression analyses showed that prior to, and after additional adjustment for circulating mercury concentrations, fish intake was inversely associated with both cardiovascular (HR 0.75, 95% CI 0.58-0.96; and, HR 0.75, 95% CI 0.58-0.97, respectively) and all-cause mortality (HR 0.84, 95% CI 0.72-0.97; and, HR 0.86, 95% CI 0.74-0.99, respectively). Secondary analyses accounting for marine-derived n-3 PUFAs intake revealed associations of similar magnitude. In conclusion, we found no evidence of a counteracting effect conferred by circulating mercury concentrations on the associations between fish and marine-derived n-3 PUFAs intake and the risks of cardiovascular and all-cause mortality in RTRs.

KW - fish intake

KW - omega-3 polyunsaturated fatty acids

KW - mercury

KW - cardiovascular mortality

KW - all-cause mortality

KW - renal transplant recipients

KW - AMERICAN-HEART-ASSOCIATION

KW - N-3 FATTY-ACIDS

KW - CARDIOVASCULAR-DISEASE

KW - VENTRICULAR MYOCARDIUM

KW - IN-VITRO

KW - RISK

KW - OMEGA-3-FATTY-ACIDS

KW - CONSUMPTION

KW - PREVENTION

KW - SURVIVAL

U2 - 10.3390/nu10101419

DO - 10.3390/nu10101419

M3 - Article

VL - 10

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 10

M1 - 1419

ER -

ID: 65865490