Fish Intake, Circulating Mercury and Mortality in Renal Transplant Recipients

Sotomayor, C. G., Gomes-Neto, A. W., Gans, R. O. B., de Borst, M. H., Berger, S. P., Rodrigo, R., Navis, G. J., Touw, D. J. & Bakker, S. J. L., Oct-2018, In : Nutrients. 10, 10, 15 p., 1419.

Research output: Contribution to journalArticleAcademicpeer-review

Marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFAs) are inversely associated with cardiovascular and all-cause mortality in renal transplant recipients (RTRs). Recommendations to increase marine-derived n-3 PUFAs by increasing fish intake may have a drawback in concomitant stimulation of mercury intake, which could lead to higher circulating mercury concentrations and mitigation of otherwise beneficial effects of n-3 PUFAs. We aimed to monitor circulating mercury concentrations, and to prospectively evaluate whether it counteracts the potential association between fish intake and cardiovascular and all-cause mortality in a cohort of RTRs (n = 604, 53 +/- 13 years-old, 57% men) with long-term follow-up (median of 5.4 years; 121 deaths). Circulating mercury concentration (median 0.30 (IQR 0.14-0.63) mu g/L) positively associated with fish intake (std. beta = 0.21, p <0.001). Multivariable-adjusted Cox-proportional hazards regression analyses showed that prior to, and after additional adjustment for circulating mercury concentrations, fish intake was inversely associated with both cardiovascular (HR 0.75, 95% CI 0.58-0.96; and, HR 0.75, 95% CI 0.58-0.97, respectively) and all-cause mortality (HR 0.84, 95% CI 0.72-0.97; and, HR 0.86, 95% CI 0.74-0.99, respectively). Secondary analyses accounting for marine-derived n-3 PUFAs intake revealed associations of similar magnitude. In conclusion, we found no evidence of a counteracting effect conferred by circulating mercury concentrations on the associations between fish and marine-derived n-3 PUFAs intake and the risks of cardiovascular and all-cause mortality in RTRs.

Original languageEnglish
Article number1419
Number of pages15
Issue number10
Publication statusPublished - Oct-2018


  • fish intake, omega-3 polyunsaturated fatty acids, mercury, cardiovascular mortality, all-cause mortality, renal transplant recipients, AMERICAN-HEART-ASSOCIATION, N-3 FATTY-ACIDS, CARDIOVASCULAR-DISEASE, VENTRICULAR MYOCARDIUM, IN-VITRO, RISK, OMEGA-3-FATTY-ACIDS, CONSUMPTION, PREVENTION, SURVIVAL

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