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Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes

Westra, H-J., Martinez-Bonet, M., Onengut-Gumuscu, S., Lee, A., Luol, Y., Teslovich, N., Worthington, J., Martin, J., Huizinga, T., Klareskog, L., Rantapaa-Dahlqvist, S., Chen, W-M., Quinlan, A., Todd, J. A., Eyre, S., Nigrovic, P. A., Regersen, P. K. G., Rich, S. S. & Raychaudhuri, S., Oct-2018, In : Nature Genetics. 50, 10, p. 1366-1374 12 p.

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  • Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes.

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DOI

  • Harm-Jan Westra
  • Marta Martinez-Bonet
  • Suna Onengut-Gumuscu
  • Annette Lee
  • Yang Luol
  • Nikola Teslovich
  • Jane Worthington
  • Javier Martin
  • Tom Huizinga
  • Lars Klareskog
  • Solbritt Rantapaa-Dahlqvist
  • Wei-Min Chen
  • Aaron Quinlan
  • John A. Todd
  • Steve Eyre
  • Peter A. Nigrovic
  • Peter K. G. Regersen
  • Stephen S. Rich
  • Soumya Raychaudhuri

To define potentially causal variants for autoimmune disease, we fine-mapped(1,2) 76 rheumatoid arthritis (11,475 cases,15,870 controls)(3) and type 1 diabetes loci (9,334 cases, 11,111 controls)(4). After sequencing 799 1-kilobase regulatory (H3K4me3) regions within these loci in 568 individuals, we observed accurate imputation for 89% of common variants. We defined credible sets of

Original languageEnglish
Pages (from-to)1366-1374
Number of pages12
JournalNature Genetics
Volume50
Issue number10
Publication statusPublished - Oct-2018

    Keywords

  • GENOME-WIDE ASSOCIATION, SYSTEMIC-LUPUS-ERYTHEMATOSUS, INFLAMMATORY-BOWEL-DISEASE, BURROWS-WHEELER TRANSFORM, SUSCEPTIBILITY LOCI, CELL-TYPES, TYROSINE-PHOSPHATASE, GENOTYPE IMPUTATION, COMPLEX TRAIT, RISK LOCI

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