Publication
Finding the missing 'LiNCs' in celiac disease
Hrdlicková, B., 2015, [Groningen]: University of Groningen. 188 p.Research output: Thesis › Thesis fully internal (DIV)

Documents
- Title and contents
Final publisher's version, 211 KB, PDF document
- Chapter 1
Final publisher's version, 863 KB, PDF document
- Chapter 2
Final publisher's version, 1.16 MB, PDF document
- Chapter 3
Final publisher's version, 4.22 MB, PDF document
- Chapter 4
Final publisher's version, 2.37 MB, PDF document
- Chapter 5
Final publisher's version, 3.65 MB, PDF document
- Chapter 6
Final publisher's version, 2.97 MB, PDF document
- Chapter 7
Final publisher's version, 4.81 MB, PDF document
- Chapter 8
Final publisher's version, 1.31 MB, PDF document
- Appendices
Final publisher's version, 1.55 MB, PDF document
- Complete dissertation
Final publisher's version, 13.5 MB, PDF document
- Propositions
Final publisher's version, 30 KB, PDF document
The aim of my thesis project was to identify novel genetic factors predisposing to celiac disease and to investigate how they might contribute to the disease mechanism. In my thesis I describe novel genetic variants that were identified by looking at the more extreme phenotypes and/or by following-up suggestively associated GWAS variants by increasing the sample size. My results indicate that long non-coding RNAs (lncRNAs), which are a new class of RNA molecules, might be important players in the pathophysiology of celiac disease. The prediction methods I applied in this work can also be used to prioritize interesting cell types for functional studies with these long non-coding RNAs.
Translated title of the contribution | Het vinden van de ontbrekende 'LiNCs' in coeliakie |
---|---|
Original language | English |
Qualification | Doctor of Philosophy |
Awarding Institution | |
Supervisors/Advisors |
|
Award date | 11-May-2015 |
Place of Publication | [Groningen] |
Publisher | |
Print ISBNs | 978-90-367-7765-0 |
Electronic ISBNs | 978-90-367-7764-3 |
Publication status | Published - 2015 |
Download statistics
ID: 19421889