Publication

Fibrosis and Cardiac Arrhythmias

de Jong, S., van Veen, T. A. B., van Rijen, H. V. M. & de Bakker, J. M. T., Jun-2011, In : Journal of Cardiovascular Pharmacology. 57, 6, p. 630-638 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

  • Sanne de Jong
  • Toon A. B. van Veen
  • Harold V. M. van Rijen
  • Jacques M. T. de Bakker

In this review article about fibrosis and arrhythmias, we show that the amount of collagen, a normal element of the heart muscle, increases with age and in heart disease. The relation between fibrosis and electrophysiological parameters such as conduction, fractionation of electrograms, abnormal impulse initiation as well as arrhythmogenicity is discussed. Next to the amount of fibrosis, we offer data suggesting that collagen texture too plays a role in conduction slowing and arrhythmia vulnerability. Data are shown revealing that fibrosis can also be induced by reduced sodium channel and connexin43 expression. Finally contrast-enhanced magnetic resonance to detect fibrosis and ventricular tachycardia vulnerability in a noninvasive way as well as a reduction of fibrosis and arrhythmogenicity by inhibition of the renin-angiotensin-aldosterone system is discussed.

Original languageEnglish
Pages (from-to)630-638
Number of pages9
JournalJournal of Cardiovascular Pharmacology
Volume57
Issue number6
Publication statusPublished - Jun-2011

    Keywords

  • fibrosis, collagen, arrhythmias, electrophysiology, CARDIOVASCULAR MAGNETIC-RESONANCE, IDIOPATHIC DILATED CARDIOMYOPATHY, ALTERED CONNEXIN43 EXPRESSION, DELAYED CONTRAST ENHANCEMENT, LATE GADOLINIUM ENHANCEMENT, GAP JUNCTIONAL CONDUCTANCE, HYPERTROPHIC CARDIOMYOPATHY, MYOCARDIAL FIBROSIS, HEART-FAILURE, VENTRICULAR-TACHYCARDIA

ID: 5339912