Publication

Feasibility of spectral shaping for detection and quantification of coronary calcifications in ultra-low dose CT

Vonder, M., Pelgrim, G. J., Huijsse, S. E. M., Meyer, M., Greuter, M. J. W., Henzler, T., Flohr, T. G., Oudkerk, M. & Vliegenthart, R., May-2017, In : European Radiology. 27, 5, p. 2047-2054 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Vonder, M., Pelgrim, G. J., Huijsse, S. E. M., Meyer, M., Greuter, M. J. W., Henzler, T., ... Vliegenthart, R. (2017). Feasibility of spectral shaping for detection and quantification of coronary calcifications in ultra-low dose CT. European Radiology, 27(5), 2047-2054. https://doi.org/10.1007/s00330-016-4507-z

Author

Vonder, Marleen ; Pelgrim, Gert Jan ; Huijsse, Sèvrin E M ; Meyer, Mathias ; Greuter, Marcel J W ; Henzler, Thomas ; Flohr, Thomas G ; Oudkerk, Matthijs ; Vliegenthart, Rozemarijn. / Feasibility of spectral shaping for detection and quantification of coronary calcifications in ultra-low dose CT. In: European Radiology. 2017 ; Vol. 27, No. 5. pp. 2047-2054.

Harvard

Vonder, M, Pelgrim, GJ, Huijsse, SEM, Meyer, M, Greuter, MJW, Henzler, T, Flohr, TG, Oudkerk, M & Vliegenthart, R 2017, 'Feasibility of spectral shaping for detection and quantification of coronary calcifications in ultra-low dose CT', European Radiology, vol. 27, no. 5, pp. 2047-2054. https://doi.org/10.1007/s00330-016-4507-z

Standard

Feasibility of spectral shaping for detection and quantification of coronary calcifications in ultra-low dose CT. / Vonder, Marleen; Pelgrim, Gert Jan; Huijsse, Sèvrin E M; Meyer, Mathias; Greuter, Marcel J W; Henzler, Thomas; Flohr, Thomas G; Oudkerk, Matthijs; Vliegenthart, Rozemarijn.

In: European Radiology, Vol. 27, No. 5, 05.2017, p. 2047-2054.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Vonder M, Pelgrim GJ, Huijsse SEM, Meyer M, Greuter MJW, Henzler T et al. Feasibility of spectral shaping for detection and quantification of coronary calcifications in ultra-low dose CT. European Radiology. 2017 May;27(5):2047-2054. https://doi.org/10.1007/s00330-016-4507-z


BibTeX

@article{d1d70f3f84b54e2bb41fe60a29b6bded,
title = "Feasibility of spectral shaping for detection and quantification of coronary calcifications in ultra-low dose CT",
abstract = "To evaluate detectability and quantification of coronary calcifications for CT with a tin filter for spectral shaping.Phantom inserts with 100 small and 9 large calcifications, and a moving artificial artery with 3 calcifications (speed 0-30 mm/s) were placed in a thorax phantom simulating different patient sizes. The phantom was scanned in high-pitch spiral mode at 100 kVp with tin filter (Sn100 kVp), and at a reference of 120 kVp, with electrocardiographic (ECG) gating. Detectability and quantification of calcifications were analyzed for standard (130 HU) and adapted thresholds.Sn100 kVp yielded lower detectability of calcifications (9 {\%} versus 12 {\%}, p = 0.027) and lower Agatston scores (p <0.008), irrespective of calcification, patient size and speed. Volume scores of the moving calcifications for Sn100 kVp at speed 10-30 mm/s were lower (p <0.001), while mass scores were similar (p = 0.131). For Sn100 kVp with adapted threshold of 117 HU, detectability (p = 1.000) and Agatston score (p > 0.206) were similar to 120 kVp. Spectral shaping resulted in median dose reduction of 62.3 {\%} (range 59.0-73.4 {\%}).Coronary calcium scanning with spectral shaping yields lower detectability of calcifications and lower Agatston scores compared to 120 kVp scanning, for which a HU threshold correction should be developed.aEuro cent Sn100kVp yields lower detectability and lower Agatston scores compared to 120kVpaEuro cent Adapted HU threshold for Sn100kVp provides Agatston scores comparable to 120kVpaEuro cent Sn100 kVp considerably reduces dose in calcium scoring versus 120 kVp.",
keywords = "Computed tomography, Coronary arteriosclerosis, Cardiovascular Diseases, Imaging, Mass screening, ELECTRON-BEAM TOMOGRAPHY, MULTIDETECTOR ROW CT, DUAL-SOURCE CT, ARTERY CALCIUM, COMPUTED-TOMOGRAPHY, PHANTOM, AGATSTON, GENDER, MDCT, AGE",
author = "Marleen Vonder and Pelgrim, {Gert Jan} and Huijsse, {S{\`e}vrin E M} and Mathias Meyer and Greuter, {Marcel J W} and Thomas Henzler and Flohr, {Thomas G} and Matthijs Oudkerk and Rozemarijn Vliegenthart",
year = "2017",
month = "5",
doi = "10.1007/s00330-016-4507-z",
language = "English",
volume = "27",
pages = "2047--2054",
journal = "European Radiology",
issn = "0938-7994",
publisher = "SPRINGER",
number = "5",

}

RIS

TY - JOUR

T1 - Feasibility of spectral shaping for detection and quantification of coronary calcifications in ultra-low dose CT

AU - Vonder, Marleen

AU - Pelgrim, Gert Jan

AU - Huijsse, Sèvrin E M

AU - Meyer, Mathias

AU - Greuter, Marcel J W

AU - Henzler, Thomas

AU - Flohr, Thomas G

AU - Oudkerk, Matthijs

AU - Vliegenthart, Rozemarijn

PY - 2017/5

Y1 - 2017/5

N2 - To evaluate detectability and quantification of coronary calcifications for CT with a tin filter for spectral shaping.Phantom inserts with 100 small and 9 large calcifications, and a moving artificial artery with 3 calcifications (speed 0-30 mm/s) were placed in a thorax phantom simulating different patient sizes. The phantom was scanned in high-pitch spiral mode at 100 kVp with tin filter (Sn100 kVp), and at a reference of 120 kVp, with electrocardiographic (ECG) gating. Detectability and quantification of calcifications were analyzed for standard (130 HU) and adapted thresholds.Sn100 kVp yielded lower detectability of calcifications (9 % versus 12 %, p = 0.027) and lower Agatston scores (p <0.008), irrespective of calcification, patient size and speed. Volume scores of the moving calcifications for Sn100 kVp at speed 10-30 mm/s were lower (p <0.001), while mass scores were similar (p = 0.131). For Sn100 kVp with adapted threshold of 117 HU, detectability (p = 1.000) and Agatston score (p > 0.206) were similar to 120 kVp. Spectral shaping resulted in median dose reduction of 62.3 % (range 59.0-73.4 %).Coronary calcium scanning with spectral shaping yields lower detectability of calcifications and lower Agatston scores compared to 120 kVp scanning, for which a HU threshold correction should be developed.aEuro cent Sn100kVp yields lower detectability and lower Agatston scores compared to 120kVpaEuro cent Adapted HU threshold for Sn100kVp provides Agatston scores comparable to 120kVpaEuro cent Sn100 kVp considerably reduces dose in calcium scoring versus 120 kVp.

AB - To evaluate detectability and quantification of coronary calcifications for CT with a tin filter for spectral shaping.Phantom inserts with 100 small and 9 large calcifications, and a moving artificial artery with 3 calcifications (speed 0-30 mm/s) were placed in a thorax phantom simulating different patient sizes. The phantom was scanned in high-pitch spiral mode at 100 kVp with tin filter (Sn100 kVp), and at a reference of 120 kVp, with electrocardiographic (ECG) gating. Detectability and quantification of calcifications were analyzed for standard (130 HU) and adapted thresholds.Sn100 kVp yielded lower detectability of calcifications (9 % versus 12 %, p = 0.027) and lower Agatston scores (p <0.008), irrespective of calcification, patient size and speed. Volume scores of the moving calcifications for Sn100 kVp at speed 10-30 mm/s were lower (p <0.001), while mass scores were similar (p = 0.131). For Sn100 kVp with adapted threshold of 117 HU, detectability (p = 1.000) and Agatston score (p > 0.206) were similar to 120 kVp. Spectral shaping resulted in median dose reduction of 62.3 % (range 59.0-73.4 %).Coronary calcium scanning with spectral shaping yields lower detectability of calcifications and lower Agatston scores compared to 120 kVp scanning, for which a HU threshold correction should be developed.aEuro cent Sn100kVp yields lower detectability and lower Agatston scores compared to 120kVpaEuro cent Adapted HU threshold for Sn100kVp provides Agatston scores comparable to 120kVpaEuro cent Sn100 kVp considerably reduces dose in calcium scoring versus 120 kVp.

KW - Computed tomography

KW - Coronary arteriosclerosis

KW - Cardiovascular Diseases

KW - Imaging

KW - Mass screening

KW - ELECTRON-BEAM TOMOGRAPHY

KW - MULTIDETECTOR ROW CT

KW - DUAL-SOURCE CT

KW - ARTERY CALCIUM

KW - COMPUTED-TOMOGRAPHY

KW - PHANTOM

KW - AGATSTON

KW - GENDER

KW - MDCT

KW - AGE

U2 - 10.1007/s00330-016-4507-z

DO - 10.1007/s00330-016-4507-z

M3 - Article

VL - 27

SP - 2047

EP - 2054

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 5

ER -

ID: 35119565