Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetesvan Dijk, P. R., Waanders, F., Pasch, A., Logtenberg, S. J. J., Vriesendorp, T., Groenier, K. H., Hillebrands, J-L., Kleefstra, N., Gans, R. O. B., van Goor, H. & Bilo, H. J. G., 3-Mar-2020, In : Therapeutic advances in endocrinology and metabolism. 11, 11 p.
Research output: Contribution to journal › Article › Academic › peer-review
Serum calcification propensity can be monitored using the maturation time of calciprotein particles in serum (T-50 test). A shorter T-50 indicates greater propensity to calcify; this is an independent determinant of cardiovascular disease. As the intraperitoneal (IP) route of insulin administration mimics the physiology more than the subcutaneous (SC) route in persons with type 1 diabetes (T1DM), we hypothesized that IP insulin influences determinants of calcium propensity and therefore result in a longer T-50 than SC insulin administration.
Prospective, observational case-control study. Measurements were performed at baseline and at 26 weeks in age and gender matched persons with T1DM.
A total of 181 persons, 39 (21.5%) of which used IP and 142 (78.5%) SC insulin were analysed. Baseline T-50 was 356 (45) minutes. The geometric mean T-50 significantly differed between both treatment groups: 367 [95% confidence interval (CI) 357, 376] for the IP group and 352 (95% CI 347, 357) for the SC group with a difference of -15 (95% CI -25, -4) minutes, in favour of IP treatment. In multivariable analyses, the IP route of insulin administration had a positive relation on T-50 concentrations while higher age, triglycerides and phosphate concentrations had an inverse relation.
Among persons with T1DM, IP insulin administration results in a more favourable calcification propensity time then SC insulin. It has yet to be shown if this observation translates into improved cardiovascular outcomes.
|Number of pages||11|
|Journal||Therapeutic advances in endocrinology and metabolism|
|Publication status||Published - 3-Mar-2020|
- cardiovascular, insulin, intraperitoneal, phosphate, serum calcification propensity, subcutaneous, T-50, type 1 diabetes mellitus, VASCULAR CALCIFICATION, GLYCEMIC CONTROL, MEDICAL-RESEARCH, MELLITUS, ABSORPTION, DELIVERY, THERAPY, DISEASE, STATISTICS, METABOLISM