Publication

Fatigue in patients with systemic lupus erythematosus: the role of dehydroepiandrosterone sulphate

Overman, C. L., Hartkamp, A., Bossema, E. R., Bijl, M., Godaert, G. L. R., Bijlsma, J. W. J., Derksen, R. H. W. M. & Geenen, R., Dec-2012, In : Lupus. 21, 14, p. 1515-1521 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • C. L. Overman
  • A. Hartkamp
  • E. R. Bossema
  • M. Bijl
  • G. L. R. Godaert
  • J. W. J. Bijlsma
  • R. H. W. M. Derksen
  • R. Geenen

Fatigue is a major problem in systemic lupus erythematosus (SLE), but the physiological substrate of this fatigue is largely unclear. To examine if low levels of dehydroepiandrosterone (DHEA) and its sulphate DHEAS play a role in SLE fatigue, we compared: 1) DHEAS levels and fatigue between 60 female patients with SLE with low disease activity (31 using, 29 not using prednisone) and 60 age-matched healthy women, and 2) fatigue between patients with SLE with low and normal DHEAS levels. Serum DHEAS levels were determined with an Advantage Chemiluminescense System. The Multidimensional Fatigue Inventory (MFI) was used to assess fatigue. Patients were more fatigued (p = 0.39). Patients with low DHEAS levels not using prednisone reported less fatigue than those with normal DHEAS levels (p

Original languageEnglish
Pages (from-to)1515-1521
Number of pages7
JournalLupus
Volume21
Issue number14
Publication statusPublished - Dec-2012

    Keywords

  • Systemic lupus erythematosus, dehydroepiandrosterone, fatigue, prednisone, QUALITY-OF-LIFE, PLACEBO-CONTROLLED TRIAL, DISEASE-ACTIVITY, DOUBLE-BLIND, WOMEN, DEPRESSION, ASSOCIATIONS, STEROIDS, CRITERIA, HEALTH

ID: 5722830