Fatale pneumonitis door oseltamivir-resistente nieuwe influenza A(H1N1) bij een intensive-carepatiënt

Aardema, H., Tulleken, J. E., van den Biggelaar, R. J. M., Wolters, B. A., de Jager, C. M., Boucher, C. A. B. & Riezebos-Brilman, A., 2010, In : Nederlands Tijdschrift voor Geneeskunde. 154, p. A1634

Research output: Contribution to journalArticleAcademicpeer-review

A 58-year-old man was submitted to our intensive care ward with respiratory failure due to pneumonitis. He had previously been treated for non-Hodgkin lymphoma by autologous stem cell transplantation, as a result of which bone marrow function was reduced. Further analysis showed infection with new influenza A(H1N1); typing revealed an oseltamivir-resistant subpopulation (H275Y). The patient was treated with oseltamivir and intravenously with zanamivir, but died of respiratory disease progression. This is the first published case of oseltamivir-resistant new influenza A(H1N1) infection in the Netherlands.

Original languageDutch
Pages (from-to)A1634
JournalNederlands Tijdschrift voor Geneeskunde
Publication statusPublished - 2010


  • Antiviral Agents, Drug Resistance, Viral, Fatal Outcome, Humans, Immunocompromised Host, Influenza A Virus, H1N1 Subtype, Influenza, Human, Male, Middle Aged, Oseltamivir, Pneumonia, Zanamivir

ID: 24002474